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CP724714,≥98% (HPLC)

别名:CP-724714, (E)-2-Methoxy-N-[3-[4-[[3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl]amino]quinazolin-6-yl]allyl]ethanamide, 2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]-acetamide, CP-724,714

Empirical Formula (Hill Notation): C27H27N5O3 CAS号: 383432-38-0 分子量: 469.53 MDL编号: MFCD15144738 PubChem化学物质编号: 329823846
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0335
CAS号: 383432-38-0
MDL号: MFCD15144738
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$354.21

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

CP724714 is a potent and selective inhibitor of HER2/ErbB2 with an IC50 value of 10 nM. CP724714 is >640-fold selectivity against EGFR, and >1000-fold selective against InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met, JNK-2, JNK-3, ZAP-70, CDK-2 and CDK-5 in in vitro kinase assays. CP724714 had antiproliferative effects in a panel of human breast cancer cell lines.
 
CP724714 是一种有效且选择性的 HER2/ErbB2 抑制剂,IC50 值为 10 nM。 CP724714 对 EGFR 的选择性大于 640 倍,对 InsR、IRG-1R、PDGFR、VEGFR2、Abl、Src、c-Met、JNK-2、JNK-3、ZAP-70、CDK-2 的选择性大于 1000 倍 和 CDK-5 体外激酶测定。 CP724714 在一组人乳腺癌细胞系中具有抗增殖作用。
 

其他说明

CP-724714 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the CP-724714 probe summary on the Chemical Probes Portal website.
This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

创始人

Pfizer

储存温度

room temp

SMILES string

COCC(NC/C=C/C1=CC=C(N=CN=C2NC3=CC=C(OC4=CC=C(C)N=C4)C(C)=C3)C2=C1)=O

InChI

1S/C27H27N5O3/c1-18-13-21(8-11-25(18)35-22-9-6-19(2)29-15-22)32-27-23-14-20(7-10-24(23)30-17-31-27)5-4-12-28-26(33)16-34-3/h4-11,13-15,17H,12,16H2,1-3H3,(H,28,33)(H,30,31,32)/b5-4+

InChI key

LLVZBTWPGQVVLW-SNAWJCMRSA-N

Gene Information

human ... ERBB2(2064)

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16