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CP-802079 hydrochloride hydrate,≥98% (HPLC)

别名:CP802079盐酸水合物;({3-(4-Chlorophenyl)-3-[4-(thiazole-carbonyl)-phenoxy]-propyl}-methyl-amino)-acetic acid hydrochloride hydrate, N-[3-(4-Chlorophenyl)-3-[4-(2-thiazolylcarbonyl)phenoxy]propyl]-N-methyl-glycine hydrochloride hydrate

Empirical Formula (Hill Notation): C22H21ClN2O4S · xHCl · yH2O CAS号: 736175-49-8 (free base) 分子量: 444.93 (anhydrous free base basis) MDL编号: MFCD18452850 PubChem化学物质编号: 329823733 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0148
CAS号: 736175-49-8
MDL号: MFCD18452850
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$421.11

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

CP-802079 is a potent and selective glycine transporter type 1 (GlyT1) antagonist. Antagonists of GlyT1 increase levels of glycine in the synaptic cleft and, like direct glycine site agonists, they can augment NMDAR currents and NMDAR-mediated functions. CP-802,079 significantly increases the amplitude of the NMDAR currents and LTP.
 
CP-802079 是一种有效的选择性甘氨酸转运蛋白 1 (GlyT1) 拮抗剂。 GlyT1 的拮抗剂会增加突触间隙中的甘氨酸水平,并且像直接甘氨酸位点激动剂一样,它们可以增强 NMDAR 电流和 NMDAR 介导的功能。 CP-802,079 显着增加了 NMDAR 电流和 LTP 的幅度。
 

特点和优势

This compound is featured on the Glycine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here to learn more.
 

其他说明

This compound was developed by Pfizer for Neuroscience research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

very light brown

溶解性

DMSO: ≥20 mg/mL

创始人

Pfizer

储存温度

2-8°C

SMILES string

O.Cl.CN(CCC(Oc1ccc(cc1)C(=O)c2nccs2)c3ccc(Cl)cc3)CC(O)=O

InChI

1S/C22H21ClN2O4S.ClH.H2O/c1-25(14-20(26)27)12-10-19(15-2-6-17(23)7-3-15)29-18-8-4-16(5-9-18)21(28)22-24-11-13-30-22;;/h2-9,11,13,19H,10,12,14H2,1H3,(H,26,27);1H;1H2

InChI key

CVQXAUBKPDYXHF-UHFFFAOYSA-N

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16