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CP-547632 hydrochloride,≥98% (HPLC)

别名:CP547632盐酸盐;3-[(4-Bromo-2,6-difluorophenyl)methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]amino]carbonyl]amino]-4-Isothiazolecarboxamide hydrochloride, PF-01371182 hydrochloride

Empirical Formula (Hill Notation): C20H24BrF2N5O3S · HCl CAS号: 252003-71-7 分子量: 568.86 MDL编号: MFCD20268381 PubChem化学物质编号: 329823800 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0264
CAS号: 252003-71-7
MDL号: MFCD20268381
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$354.21

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

CP-547632 is a potent inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases (IC50 = 11 and 9 nM, respectively). The compound CP-547632 inhibits VEGF and basic FGF-induced angiogenesis in animal models, and inhibits growth of xenograft tumors in mice.
CP-547632 hydrochloride is a well-tolerated, orally-bioavailable ATP-competitive kinase inhibitor. It is currently in clinical trials for the treatment of human malignancies.
 
CP-547632 是 VEGFR-2 和碱性成纤维细胞生长因子 (FGF) 激酶的有效抑制剂(IC50 分别为 11 和 9 nM)。 化合物 CP-547632 在动物模型中抑制 VEGF 和碱性 FGF 诱导的血管生成,并抑制小鼠异种移植肿瘤的生长。
CP-547632 盐酸盐是一种耐受性良好、口服生物可利用的 ATP 竞争性激酶抑制剂。 它目前正在临床试验中用于治疗人类恶性肿瘤。
 

其他说明

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

创始人

Pfizer

储存温度

room temp

SMILES string

NC(C1=C(NC(NCCCCN2CCCC2)=O)SN=C1OCC3=C(F)C=C(Br)C=C3F)=O.[H]Cl

InChI

1S/C20H24BrF2N5O3S.ClH/c21-12-9-14(22)13(15(23)10-12)11-31-18-16(17(24)29)19(32-27-18)26-20(30)25-5-1-2-6-28-7-3-4-8-28;/h9-10H,1-8,11H2,(H2,24,29)(H2,25,26,30);1H

InChI key

NNPJZJJMQDXYGN-UHFFFAOYSA-N

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

预防措施声明

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16