过滤

CP101606甲磺酸酯，CP-101606 mesylate；≥98% (HPLC)

别名：CP-101,60 mesylate；甲磺酸(1S,2S)-1-(4-羟基苯基)-2-(4-羟基-4-苯基哌啶基)-1-丙醇甲磺酸酯；甲磺酸丙醇酯-1-（1S，2S）-1-（4-羟基苯基）-2-（4-羟基-4-苯基哌啶-1-基）-1-丙醇甲磺酸酯；(1S,2S)-1-(4-Hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol mesylate, CP-101606-27, (1S,2S)-1-(4-Hydroxy-phenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol mesylate, Traxoprodil mesylate

Empirical Formula (Hill Notation): C20H25NO3 · CH4O3S CAS号: 188591-67-5 分子量: 423.52 MDL编号: MFCD12546332 PubChem化学物质编号: 329823794 NACRES: NA.77

制造商品牌: 西格玛 Sigma-Aldrich

货号（SKU）: PZ0255

CAS号: 188591-67-5

MDL号: MFCD12546332

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目录价.SKU-Variant

5mg
25mg [+¥3,404.12]

¥1,391.58

数量:

说明

生化/生理作用

CP-101,606 is an NR2B (N-methyl D-aspartate receptor subtype 2B) subunit antagonist, that can increase dyskinesia. It reduces Ca²⁺/calmodulin-dependent protein kinase II level, at threonine-286 hyperphosphorylation (pCaMKII-Thr286).[1] It has no effect on the α1-adrenergic receptors.[2] CP-101,606 has the ability to inhibits the habits, stimulated by cocaine. It also possesses hallucinogenic properties.[3]

CP-101606 mesylate (Traxoprodil mesylate) is a potent noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, selective for the NR2B subunit. CP-101606 mesylate has been shown to be neuroprotective in animal models of brain injury and stroke.

其他说明

This compound was developed by Pfizer for Neuroscience research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律信息

Sold for research purposes under agreement from Pfizer Inc.

Pfizer is a registered trademark of Pfizer, Inc.

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer^®

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

创始人

Pfizer

储存温度

room temp

SMILES string

OC1=CC=C([C@H](O)[C@H](C)N2CCC(O)(C3=CC=CC=C3)CC2)C=C1.CS(=O)(O)=O

InChI

1S/C20H25NO3.CH4O3S/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-14-21)17-5-3-2-4-6-17;1-5(2,3)4/h2-10,15,19,22-24H,11-14H2,1H3;1H3,(H,2,3,4)/t15-,19+;/m0./s1

InChI key

OZBWUANKVIMZIA-WRRDZZDISA-N

安全信息

象形图

GHS06,GHS09

警示用语：

Danger

危险声明

H301 - H319 - H400

预防措施声明

P273 - P301 + P310 + P330 - P305 + P351 + P338

危险分类

Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2

储存分类代码

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

商品规格

属性名称	属性值
储存温度 Storage temp.	常温阴凉避光
全球实时库存 Availability √	美国St. Louis ≥ 20 \| 欧洲Eur. ≥ 16 \| 東京Tokyo ≥ 5 \| 香港与北京 ≥ 20

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