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CP-101606 mesylate,≥98% (HPLC)

别名:CP101606甲磺酸酯;CP-101,60 mesylate, (1S,2S)-1-(4-Hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol mesylate, CP-101606-27, (1S,2S)-1-(4-Hydroxy-phenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol mesylate, Traxoprodil mesylate

Empirical Formula (Hill Notation): C20H25NO3 · CH4O3S CAS号: 188591-67-5 分子量: 423.52 MDL编号: MFCD12546332 PubChem化学物质编号: 329823794 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0255
CAS号: 188591-67-5
MDL号: MFCD12546332
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$354.21

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

CP-101606 mesylate (Traxoprodil mesylate) is a potent noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, selective for the NR2B subunit. CP-101606 mesylate has been shown to be neuroprotective in animal models of brain injury and stroke.
CP-101,606 is an NR2B (N-methyl D-aspartate receptor subtype 2B) subunit antagonist, that can increase dyskinesia. It reduces Ca2+/calmodulin-dependent protein kinase II level, at threonine-286 hyperphosphorylation (pCaMKII-Thr286). It has no effect on the α1-adrenergic receptors. CP-101,606 has the ability to inhibits the habits, stimulated by cocaine. It also possesses hallucinogenic properties.
 
CP-101606 mesylate (Traxoprodil mesylate) 是一种有效的非竞争性 N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂,对 NR2B 亚基具有选择性。 CP-101606 mesylate 已被证明在脑损伤和中风的动物模型中具有神经保护作用。
CP-101,606 是一种 NR2B(N-甲基 D-天冬氨酸受体亚型 2B)亚基拮抗剂,可增加运动障碍。 它在苏氨酸 286 过度磷酸化 (pCaMKII-Thr286) 时降低 Ca2+/钙调蛋白依赖性蛋白激酶 II 水平。 它对α1-肾上腺素能受体没有影响。 CP-101,606 具有抑制可卡因刺激的习惯的能力。 它还具有致幻特性。
 

其他说明

This compound was developed by Pfizer for Neuroscience research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

创始人

Pfizer

储存温度

room temp

SMILES string

OC1=CC=C([C@H](O)[C@H](C)N2CCC(O)(C3=CC=CC=C3)CC2)C=C1.CS(=O)(O)=O

InChI

1S/C20H25NO3.CH4O3S/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-14-21)17-5-3-2-4-6-17;1-5(2,3)4/h2-10,15,19,22-24H,11-14H2,1H3;1H3,(H,2,3,4)/t15-,19+;/m0./s1

InChI key

OZBWUANKVIMZIA-WRRDZZDISA-N

 

安全信息

象形图

Skull and crossbonesEnvironment

警示用语:

Danger

危险声明

RIDADR

UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16