sevenspikes.themes.common.filters
sevenspikes.themes.common.closemenu

CP-100356 monohydrochloride,>98% (HPLC)

别名:4-(3,4-二氢-6,7-二甲氧基-2(1H)-异喹啉基)-N-2-(3,4-二甲氧基苯基)乙基-6,7-二甲氧基-2-喹唑啉胺单盐酸盐;4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-2-(3,4-dimethoxyphenyl)ethyl-6,7-dimethoxy-2-quinazolinamine monohydrochloride

Empirical Formula (Hill Notation): C31H36N4O6 · HCl CAS号: 142715-48-8 分子量: 597.10 MDL编号: MFCD00911858 PubChem化学物质编号: 329823745 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0171
CAS号: 142715-48-8
MDL号: MFCD00911858
增值税发票 √ 免费送货 √ 订货电话:010-68689484
$404.86

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. The compound has low uM to nM potency for inhibiting several MDR-1 substrates (calcein-AM, digoxin) in transfected MDCKII cells. CP-100356 also inhibits prazosin transport in human breast cancer resistance protein (BCRP)-transfected MDCKII cells, suggesting that it acts as a dual inhibitor. CP-100356 does not inhibit multidrug resistance-associated protein 2 (MPR2 IC50 >15 mM).
 

特点和优势

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here to learn more.
 

其他说明

This compound was developed by Pfizer for ADME/Tox research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

测定

>98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to off-white

溶解性

DMSO: >5 mg/mL

创始人

Pfizer

储存温度

2-8°C

SMILES string

Cl.COc1ccc(CCNc2nc(N3CCc4cc(OC)c(OC)cc4C3)c5cc(OC)c(OC)cc5n2)cc1OC

InChI

1S/C31H36N4O6.ClH/c1-36-24-8-7-19(13-25(24)37-2)9-11-32-31-33-23-17-29(41-6)28(40-5)16-22(23)30(34-31)35-12-10-20-14-26(38-3)27(39-4)15-21(20)18-35;/h7-8,13-17H,9-12,18H2,1-6H3,(H,32,33,34);1H

InChI key

WWCHXVYTCMPAMV-UHFFFAOYSA-N

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16