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顺式-4-((2-((1H-苯并[d]咪唑-6-基)氨基)喹唑啉-8-基)氧基)环己醇,cis-4-​[[2-​(1H-​Benzimidazol-​6-​ylamino)​-​8-​quinazolinyl]​oxy]​-​cyclohexanol

CasNo:1792999-26-8;分子式:C21H21N5O2;分子量:375.42
制造商品牌: 加拿大TRC
货号(SKU): B197005
CAS号: 1792999-26-8
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Product Description

Catalogue NumberB197005
Chemical Namecis-4-​[[2-​(1H-​Benzimidazol-​6-​ylamino)​-​8-​quinazolinyl]​oxy]​-​cyclohexanol
SynonymsNCB-​0846
CAS Number1792999-26-8
Molecular FormulaC₂₁H₂₁N₅O₂
AppearanceOff-White to Light Yellow Solid
Molecular Weight375.42
Storage-20°C Freezer
SolubilityDMSO (Slightly), Methanol (Slightly)
CategoryStandards; Enzyme Activators and Inhibitors;
Applicationscis-4-​[[2-​(1H-​Benzimidazol-​6-​ylamino)​-​8-​quinazolinyl]​oxy]​-​cyclohexanol inhibits Traf2 and Nck-interacting protein kinase (TNIK). TNIK is involved with Canonical Wnt/b-catenin signalling, which has regulatory roles in maintaining intestinal stem cells and aberration in this pathway has been implicated in colorectal carcinogenesis. TNIK is a therapeutic target.
ReferencesMasuda, M., et al.: Nat Commun. 7, 12586 (2016); Masuda, M., et al.: Pharmacol. Ther. 156, 1 (2017);
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32