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CM琼脂糖凝胶FF [高流速],CM Sepharose Fast Flow [GE Cytiva]

CM Sepharose Fast Flow是基于完善的Sepharose Fast Flow离子交换平台的弱阳离子交换剂,广泛用于研究和工业应用中的制备性蛋白质分离。订货号:17071910;17071905;17071901;17071960;17-0719-10;17-0719-05;17-0719-01;17-0719-60
货号(SKU): 17071901
CAS号: 68894-07-5
MDL号: MFCD00146478
增值税发票 √ 免费货运 [顺丰 联邦] √
₹ 12,805.82

产品描述

CM Sepharose Fast Flow is a weak cation exchanger based on the well established Sepharose Fast Flow ion exchange platform, extensively used for preparative protein separations in both research and industrial applications.

CM 琼脂糖凝胶®用于亲和层析、蛋白层析和离子交换层析。CM 琼脂糖凝胶®已被用于研究膳食补充剂和表征蝰蛇毒液的生化和酶学属性。

性质

CM Sepharose Fast Flow is a weak cation exchanger based on the well established Sepharose Fast Flow ion exchange platform, extensively used for preparative protein separations in both research and industrial applications.

  • Well-proven weak cation exchanger developed for industrial downstream processes
  • Used extensively for capture and intermediate purification of a wide range of approved biopharmaceuticals
  • The industry standard for ion exchange chromatography during recent decades
  • High chemical stability allows for well proven CIP and sanitization protocols
  • The hydrophilic nature of the base matrix ensures low levels of non-specific binding leading to low levels of host cell-derived impurities in the elution pool.

CM Sepharose Fast Flow is part of the Sepharose Fast Flow ion exchange platform, which has been the industrial standard for ion exchange chromatography during recent decades. It is composed of cross-linked, 6% agarose particles, with carboxymethyl (CM) weak cation exchange groups. CM Sepharose Fast Flow has high chemical stability, allowing well proven cleaning-in-place (CIP) and sanitization protocols. Scale-up with CM Sepharose Fast Flow is straight forward and the resin is available in a range of pre-packed process development tools.

As member of the BioProcess resin range, CM Sepharose Fast Flow meets industrial demands with security of supply and comprehensive technical and regulatory support.

规格

ParameterCM Sepharose Fast Flow
BioProcess resinYes 
LigandCarboxymethyl 
Particle size, d50V1~90 µm 
Ion Exchanger TypeWeak cation exchanger 
Matrixcross-linked agarose, 6%, spherical 
Particle Size45 μm-165 μm 
Ionic Capacity0.09-0.13 mmol H+/ml medium 
pH stability, operational24–13 
pH stability, CIP32–14 
pH ligand fully charged4Above 6 
Pressure/Flow Specification300-600 cm/h, 100 kPa, XK 50/30 column, bed height 15 cm 
Exclusion limit (Mr) (globular proteins)~4 × 10⁶ 
Storage4 to 30°C, 20% Ethanol 
Chemical stability5Stable to commonly used aqueous buffers:1.0 M NaOH, 8 M urea, 8 M guanidine hydrochloride, 70% ethanol 
  • 1Median particle size of the cumulative volume distribution.
  • 2pH range where resin can be operated without significant change in function.
  • 3pH range where resin can be subjected to cleaning- or sanitization-in-place without significant change in function.
  • 4pH range where ligand is fully charged.
  • 51 M NaOH and acetic acid should be used only for cleaning purposes.


安全信息

个人防护装备 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK德国 3
商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 190 | 欧洲Eur. ≥ 66 | 東京Tokyo ≥ 82 | 香港与北京 ≥ 55
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