CJ-13610，≥98% (HPLC)

图片 CJ-13610，≥98% (HPLC)
别名：CJ13610；四氢-4-[3-[[4-(2-甲基-1H-咪唑-1-基)苯基]硫代]苯基]-2H-吡喃-4-甲酰胺；Tetrahydro-4-3-4-(2-methyl-1H-imidazol-1-yl)phenylthiophenyl-2H-pyran-4-carboxamide

Empirical Formula (Hill Notation): C22H23N3O2S CAS号: 179420-17-8 分子量: 393.50 MDL编号: MFCD00948114 PubChem化学物质编号: 329825216 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: SML0187
CAS号: 179420-17-8
MDL号: MFCD00948114
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¥1,563.90

说明

应用

CJ-13610 may be used to study 5-lipoxygenase-mediated cell signaling.
 

生化/生理作用

CJ-13,610 is a potent inhbititor of 5-lipoxygenase (5-LO) activity (IC50 = 70 nM).
CJ-13610 inhibits the biosynthesis of leukotriene B4 and regulates the IL-6 mRNA expression in macrophages. It reduces fibrosis and necroinflammation of liver in carbon tetrachloride-treated mice.[1]
 

特点和优势

This compound is featured on the Leukotriene Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 
 

属性

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

储存条件

desiccated

颜色

white to tan

溶解性

DMSO: ≥10 mg/mL

创始人

Pfizer

储存温度

2-8°C

SMILES string

Cc1nccn1-c2ccc(Sc3cccc(c3)C4(CCOCC4)C(N)=O)cc2

InChI

1S/C22H23N3O2S/c1-16-24-11-12-25(16)18-5-7-19(8-6-18)28-20-4-2-3-17(15-20)22(21(23)26)9-13-27-14-10-22/h2-8,11-12,15H,9-10,13-14H2,1H3,(H2,23,26)

InChI key

VPTONMHDLLMOOV-UHFFFAOYSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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