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CJ-13610,≥98% (HPLC)

别名:CJ13610;Tetrahydro-4-3-4-(2-methyl-1H-imidazol-1-yl)phenylthiophenyl-2H-pyran-4-carboxamide

Empirical Formula (Hill Notation): C22H23N3O2S CAS号: 179420-17-8 分子量: 393.50 MDL编号: MFCD00948114 PubChem化学物质编号: 329825216 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML0187
CAS号: 179420-17-8
MDL号: MFCD00948114
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$368.83

说明

应用

CJ-13610 may be used to study 5-lipoxygenase-mediated cell signaling.
CJ-13610 可用于研究 5-脂氧合酶介导的细胞信号传导。
CJ-13610 抑制白三烯 B4 的生物合成并调节巨噬细胞中的 IL-6 mRNA 表达。 它减少了四氯化碳处理小鼠肝脏的纤维化和坏死性炎症。
CJ-13,610 是一种有效的 5-脂氧合酶 (5-LO) 活性抑制剂 (IC50 = 70 nM)。
 

包装

5, 25 mg in glass bottle
 

生化/生理作用

CJ-13610 inhibits the biosynthesis of leukotriene B4 and regulates the IL-6 mRNA expression in macrophages. It reduces fibrosis and necroinflammation of liver in carbon tetrachloride-treated mice.
CJ-13,610 is a potent inhbititor of 5-lipoxygenase (5-LO) activity (IC50 = 70 nM).
 

特点和优势

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is featured on the Leukotriene Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
 

属性

测定

≥98% (HPLC)

形式

powder

储存条件

desiccated

颜色

white to tan

溶解性

DMSO: ≥10 mg/mL

创始人

Pfizer

储存温度

2-8°C

SMILES string

Cc1nccn1-c2ccc(Sc3cccc(c3)C4(CCOCC4)C(N)=O)cc2

InChI

1S/C22H23N3O2S/c1-16-24-11-12-25(16)18-5-7-19(8-6-18)28-20-4-2-3-17(15-20)22(21(23)26)9-13-27-14-10-22/h2-8,11-12,15H,9-10,13-14H2,1H3,(H2,23,26)

InChI key

VPTONMHDLLMOOV-UHFFFAOYSA-N

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16