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Capto高分辨率多峰层析树脂,Capto MMC ImpRes multimodal chromatography resin

这种树脂专为现代大型制造商设计,用于单克隆抗体 (mAb) 和其他生物分子的高分辨率精制。17371605;17371603;17371602;17371601;17371604
货号(SKU): 17371603
增值税发票 √ 免费送货 √ 订货电话:010-68689484
¥43,391

Designed for modern, large-scale manufacturers, this resin is used for high-resolution polishing of monoclonal antibodies (mAbs) and other biomolecules.

通过高分辨率磁珠和配体选择性实现高产量。
有效去除 mAb 工艺中的聚集体、病毒和主要污染物。
支持使用平台方法进行 mAb 工艺开发。
显示 pH 值和盐分的广泛操作窗口。
适用于抗体片段的抛光。
Resin 满足工业对供应安全性、强大性能和监管支持的需求。
解决具有挑战性的纯化问题
与传统的离子交换剂相比,弱阳离子交换多峰配体可在较宽的 pH 和盐窗口中实现高选择性。这种选择性允许在各种工艺条件下使用 Capto MMC ImpRes 来解决具有挑战性的纯化问题。

宽阔的操作窗口,简化加工
Capto MMC ImpRes 的多峰阳离子交换剂配体通过多种类型的相互作用与目标分子相互作用,包括氢键和疏水相互作用。

Capto MMC ImpRes 可用于 mAb 纯化过程中的初始或最终精制步骤。它还可以用于纯化抗体片段,例如域抗体 (DAb)。

电导率和/或 pH 值的宽操作窗口简化了下游过程,因为可以省略蛋白质 A 步骤之后的调节。使用灵敏的 mAb 时,宽广的操作窗口简化了条件的优化。

  • High yields achieved through the high-resolution beads and selectivity of the ligand.
  • Efficient removal of aggregates, viruses, and main contaminants in mAb processes.
  • Enables use of a platform approach to mAb process development.
  • Displays a broad operational window for pH and salt.
  • Suitable for polishing of antibody fragments.
  • Resin fulfills industrial demands for security of supply, robust performance, and regulatory support.

Solve challenging purification problems

The weak cation exchange multimodal ligand enables high selectivity in a broad pH and salt window compared with traditional ion exchangers. This selectivity allows the use of Capto MMC ImpRes in a variety of process conditions to solve challenging purification problems.

Wide operation window for simplified processing

The multimodal cation exchanger ligand of Capto MMC ImpRes interacts with the target molecule through multiple types of interactions, including hydrogen bonding and hydrophobic interactions.

Capto MMC ImpRes can be used for initial or final polishing steps in mAb purification processes. It can also be used for polishing of antibody fragments such as domain antibodies (DAbs).

The wide window of operation for conductivity and/or pH simplifies the downstream process, because conditioning after the protein A step can be omitted. When working with sensitive mAbs, the wide window of operation simplifies optimization of conditions.

 

ParameterCapto MMC ImpRes, 1 L
BioProcess resinYes 
LigandMultimodal weak cation exchanger 
Particle size, d50V1~40 μm 
MatrixHigh-flow agarose 
Binding Capacity/ml Chromatography Medium60-90 mg Mab/mL 
Ligand density25-39 µmol/ml 
pH stability, operational23–12 
pH stability, CIP32–14 
Pressure/Flow Specification4300 kPa 
Storage4°C to 30°C in 20% ethanol, 0.2 M sodium acetate 
Chemical stabilityCommonly used aqueous buffers, 1 M acetic acid, 1 M NaOH, 2 M NaCl, 5% 1-propanol, 30% isopropanol, 70% ethanol 
Avoid UsingOxidizing agents, cationic detergents 
Pack size1 L 
  • 1Median particle size of the cumulative volume distribution.
  • 2pH range where resin can be operated without significant change in function.
  • 3pH interval where the medium can be subjected to cleaning-in-place without significant change in function.
  • 4at min. 220 cm/h, 1 m diameter column, 20 cm bed height
商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16