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Capto高分辨率多峰层析树脂,Capto adhere ImpRes multimodal chromatography resin

这种多峰强阴离子交换树脂支持在蛋白 A 捕获步骤下游纯化方案的第二或第三步中进行有效的 mAb 精制。
货号(SKU): 17371503
增值税发票 √ 免费送货 √ 订货电话:010-68689484
¥45,884

This multimodal, strong anion exchange resin supports effective mAb polishing in the second or third step of a purification scheme downstream of the protein A capture step.

通过高分辨率磁珠和配体选择性实现高产量。
有效去除 mAb 工艺中的聚集体、病毒和主要污染物。
支持使用平台方法进行 mAb 工艺开发。
允许分离 mAb 带电变体。
树脂满足工业对供应安全、稳健性能和监管支持的需求
帮助解决净化问题
Capto adhere ImpRes 的多峰阴离子交换剂配体被固定在基础基质上,并通过多种类型的相互作用与目标分子相互作用。

阴离子多峰配体的高选择性允许在各种工艺条件下操作,以解决具有挑战性的纯化问题。 污染物如 DNA、宿主细胞蛋白、浸出的蛋白 A、聚集体和病毒被有效去除。

  • High yields achieved through the high-resolution beads and selectivity of the ligand.
  • Efficient removal of aggregates, viruses, and main contaminants in mAb processes.
  • Enables use of a platform approach to mAb process development.
  • Allows separation of mAb charged variants.
  • Resin fulfills industrial demands for security of supply, robust performance, and regulatory support

Helps solve purification problems

The multimodal anion exchanger ligand of Capto adhere ImpRes is immobilized to the base matrix and interacts with the target molecule through multiple types of interactions.

The high selectivity of the anion multimodal ligand allows operation in a variety of process conditions to solve challenging purification problems. Contaminants such as DNA, host cell proteins, leached protein A, aggregates, and viruses are efficiently removed.

 

ParameterCapto adhere ImpRes, 1 L
BioProcess resinYes 
LigandMultimodal strong anion exchanger 
Particle size, d50V1~40 μm 
MatrixHigh-flow agarose 
Binding Capacity/ml Chromatography Medium45-85 mg Mab/mL 
Ionic Capacity0.08-0.11 mmol Cl-/ml medium 
pH stability, operational23–12 
pH stability, CIP32–14 
Pressure/Flow Specification4300 kPa 
Storage4°C to 30°C in 20% ethanol 
Chemical stabilityCommonly used aqueous buffers, 1 M acetic acid, 1 M NaOH, 2 M NaCl, 5% 1-propanol, 30% isopropanol, 70% ethanol 
Avoid UsingOxidizing agents, anionic detergents 
Certificate of AnalysisYes 
Pack size1 L 
  • 1Median particle size of the cumulative volume distribution.
  • 2pH range where resin can be operated without significant change in function.
  • 3pH interval where the medium can be subjected to cleaning-in-place without significant change in function.
  • 4at min. 220 cm/h, 1 m diameter column, 20 cm bed height
商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16