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Capto粘附多峰层析树脂,Capto adhere multimodal chromatography resin

一种多模式阴离子交换树脂,设计用于以工艺规模对单克隆抗体进行蛋白 A 后纯化。 它也可以用于结合/洗脱模式。17544404;17544401;17544403;17544405;17544410;17544460
货号(SKU): 17544403
增值税发票 √ 免费送货 √ 订货电话:010-68689484
€418.45

A multimodal anion exchange resin designed for post-protein A purification of monoclonal antibodies at process scale. It can also be used in bind/elute mode.

pH 值和电导率的宽操作窗口。
Resin 满足工业对供应安全性、强大性能和监管支持的需求。
具有蛋白 A 亲和性的两步色谱过程可节省时间并降低运营成本。
去除污染物至配方水平。
流通模式下的高容量和生产率。
与传统 IEX 树脂不同的选择性
Capto粘附由刚性、高流动性琼脂糖基质和新型多峰配体组成。与传统离子交换 (IEX) 树脂相比,强多峰配体提供了不同的选择性。

mAb 色谱过程的第二步
Captoadher 可以一步去除关键污染物,例如 DNA、宿主细胞蛋白 (HCP)、浸出的蛋白 A、二聚体和更大的聚集体以及病毒。与蛋白 A 捕获步骤(如 MabSelect SuRe)一起,Capto adhere 允许设计用于 mAb 的两步色谱过程。

卡托坚持家族的一部分
为获得 Capto adhere 的最佳性能,建议筛选和优化加载条件,最好使用现代高通量工艺开发工具,例如 PreDictor 96 孔过滤板。

  • Wide operational window of pH and conductivity.
  • Resin fulfills industrial demands for security of supply, robust performance, and regulatory support.
  • Two-step chromatographic process with protein A affinity, saves time and cuts operating costs.
  • Removes contaminants to formulation levels.
  • High capacity and productivity in flow-through mode.

Different selectivity from traditional IEX resins

Capto adhere is composed of a rigid, high-flow agarose matrix and a novel multimodal ligand. The strong multimodal ligand gives a different selectivity compared to traditional ion exchange (IEX) resins.

Second step in mAb chromatographic process

Capto adhere can remove key contaminants such as DNA, host cell proteins (HCP), leached protein A, dimers and larger aggregates, and viruses in a single step. Together with a Protein A capture step, like MabSelect SuRe, Capto adhere allows the design of a two-step chromatographic process for mAbs.

Part of the Capto adhere family

For optimal performance of Capto adhere, screening and optimization of loading conditions is recommended, preferably using modern high-throughput process development tools, such as PreDictor 96-well filter plates.

 

ParameterCapto adhere, 1 L
BioProcess resinYes 
LigandN-benzyl-n-methyl ethanolamine 
Particle size, d50V1~75 µm 
Ion Exchanger TypeMultimodal strong anion exchanger 
MatrixHighly cross-linked agarose 
Ionic Capacity0.09-0.12 mmol Cl-/ml medium 
pH stability, operational23–12 
pH stability, CIP32–14 
Pressure/Flow Specification300 kPa at 600 cm/h, 1 m diameter column, 20 cm bed height 
Storage4 to 30°C, 20% Ethanol 
Estimated shelf life from manufacture date5 years 
Chemical stability4Commonly used aqueous buffers, 1 M acetic acid, 1 M sodium hydroxide 
Certificate of AnalysisYes 
Pack size1 L 
  • 1Median particle size of the cumulative volume distribution.
  • 2pH range where resin can be operated without significant change in function.
  • 3pH interval where the medium can be subjected to, for cleaning- or sanitization-in-place.
  • 4No significant change in ionic binding capacity and carbon content after one week storage in 1 M NaOH at 40°C.
商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16