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BX471,≥98% (HPLC)

别名:ZK-811752;(R)-1-(5-氯-2-(2-(4-(4-氟苄基)-2-甲基哌嗪-1-基)-2-氧代乙氧基)苯基)脲;N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea

CAS号 217645-70-0 (free acid) 经验分子式(希尔表示法) C21H24ClFN4O3 分子量 434.89 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML0020
CAS号: 217645-70-0
MDL号: MFCD09859709
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¥2,023.28

产品描述

Application

BX471 has been used in chemotaxis assay to study the responses of HEK293 cells expressing human C-C motif chemokine receptor 1 (CCR1) to CC motif ligand 3 (CCL3)-induced cell migration.[5] It has also been used as a CCR1 inhibitor to assess the effects of CCR1 on the migration and epithelial-mesenchymal transition (EMT).[6]

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

BX471 blocks CCR1 and downregulates the mRNA expression of ICAM-1, P-selectin and E-selectin.[1] It decreases the inflammatory responses in sepsis,[1] prevents monocyte recruitment in inflammation sites in rheumatoid arthritis patients[2] and inhibits interstitial leukocyte recruitment and fibrosis in mouse model of lupus nephritis.[3]

BX471 is an orally active, CCR-1 specific antagonist. It displaces the endogenous CCR-1 ligands MIP-1a, RANTES and MCP-3 (Ki range 1-5 nM). BX471 inhibits CCR-1 effects in leukocytes, including calcium mobilization and migration.

Features and Benefits

This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

性质

Quality Level  100
assay  ≥98% (HPLC)
form  powder
storage condition  desiccated
color  white to tan
solubility  DMSO: ≥25 mg/mL
originator  Bayer
storage temp.  2-8°C


安全信息

危害码 (欧洲) Xn,N
风险声明 (欧洲) 22-50
安全声明 (欧洲) 61
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 60 | 欧洲Eur. ≥ 21 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 10