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BGP-15,≥99% (HPLC)

别名:(z)-N-(2-羟基-3-(哌啶-1-基)丙氧基)烟酰胺双盐酸盐;N-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotinimidamide dihydrochloride

CAS:66611-37-8;分子式:C14H24Cl2N4O2;分子量:351.27
制造商品牌: BSZH 科学公司
货号(SKU): S06088
CAS号: 66611-37-8
MDL号: MFCD21603901
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¥982.00

产品描述

产品可溶于DMSO(70 mg/mL)、乙醇和水。

Application

一种具有PARP抑制活性的烟酸胺肟衍生物。

As a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase(PARP), PARP inhibitors are considered a potential treatment for stroke and myocardial infarction.
In vitro: Previous study showed that BGP-15 at 200 μM could prevent the imatinib-induced oxidative damages, attenuate the depletion of high-energy phosphates, alter the signaling effect of imatinib by preventing p38 MAP kinase and JNK activation, and also induce the Akt and GSK-3β phosphorylation
In vivo: In-vivo study indicated that BGP-15 improved cardiac function and reduced arrhythmic episodes in two HF and AF mouse models. In these models, BGP-15 was associated with increased phosphorylation of IGF1R. Moreover, cardiac-specific IGF1R transgenic overexpression in mice recapitulated the protection caused by BGP-15. The authors further demonstrated that BGP-15 with IGF1R could provide protection independent of phosphoinositide 3-kinase-Akt and heat-shock protein 70.

作为多聚ADP核糖聚合酶(PARP)酶的药理抑制剂,PARP抑制剂被认为是中风和心肌梗塞的潜在治疗方法。
体外:先前的研究表明,200μM的BGP-15可以预防伊马替尼诱导的氧化损伤,减弱高能磷酸盐的消耗,通过防止p38 MAP激酶和JNK活化来改变伊马替尼的信号传导作用,并诱导 Akt和GSK-3β磷酸化
体内:体内研究表明,在两种HF和AF小鼠模型中,BGP-15改善了心脏功能,并减少了心律失常发作。 在这些模型中,BGP-15与IGF1R的磷酸化增加有关。 此外,小鼠心脏特异性IGF1R转基因过表达概括了由BGP-15引起的保护作用。 作者进一步证明,带有IGF1R的BGP-15可以提供独立于磷酸肌醇3激酶-Akt和热休克蛋白70的保护。

性质

Iupac NameN-(2-hydroxy-3-(piperidin-1-yl)propoxy)nicotinimidamide dihydrochloride
Inchi Code1S/C14H22N4O2.2ClH/c15-14(12-5-4-6-16-9-12)17-20-11-13(19)10-18-7-2-1-3-8-18;;/h4-6,9,13,19H,1-3,7-8,10-11H2,(H2,15,17);2*1H
Inchi KeyISGGVCWFTPTHIX-UHFFFAOYSA-N


安全信息

符号 
GHS07  GHS07
信号词 Warning
危害声明 H302
警示性声明 P301 + P312 + P330
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16