B-cell maturation antigen (BCMA) or tumor necrosis factor receptor superfamily member 17(TNFRSF17), a member of the tumor necrosis factor (TNF) receptor superfamily, binds to B-cell–activating factor (BAFF) and a proliferation-inducing ligand (APRIL). BCMA is expressed on mature B-cells and other B-cell lines.
[1][2] The human BCMA gene codes for a 184 amino acid type I transmembrane protein, which contains a 54 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 107 amino acid cytoplasmic domain. Recombinant soluble human BCMA is a 50 amino acid polypeptide (5.3kDa) comprising the TNFR homologous region of the BCMA protein.