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BAZ2-ICR,≥98% (HPLC)

别名:4-{4-(1-甲基-1H-吡唑-4-基)-1-[2-(1-甲基-1H-吡唑-4-基)-乙基]-1H-咪唑-5-基}- 苄腈;4-{4-(1-Methyl-1H-pyrazol-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)-ethyl]-1H-imidazol-5-yl}-benzonitrile

Empirical Formula (Hill Notation): C20H19N7 分子量: 357.41 MDL编号: MFCD28166490 PubChem化学物质编号: 329825762 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML1276
CAS号: 1665195-94-7
MDL号: MFCD28166490
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$381.88

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

BAZ2-ICR is a chemical probe for BAZ2A/B bromodomains with >100-fold selectivity over other bromodomains, with the exception of CECR2 (15-fold selectivity). BAZ2A is an essential component of the nucleolar remodeling complex (NoRC), which mediates recruitment of histone modifyine enzymes and DNA methylase involved in the silencing of ribosomal RNA transcription by RNA polymerase I. BAZ2B is believed to be involved in regulating nucleosome mobilization along linear DNA. BAZ2-ICR binds to BAZ2A with a KD of 109 nM (ITC) and to BAZ2B with a KD of 170 nM (ITC). BAZ2-ICR also shows accelerated Fluorescence recovery after photobleaching (FRAP) recovery at 1 μM in the BAZ2A FRAP assay. For full characterization details, please visit the BAZ2-ICR probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
 
BAZ2-ICR 是一种针对 BAZ2A/B 溴结构域的化学探针,其选择性比其他溴结构域高 100 倍以上,但 CECR2 除外(选择性 15 倍)。 BAZ2A 是核仁重塑复合物 (NoRC) 的重要组成部分,它介导组蛋白修饰酶和 DNA 甲基化酶的募集,这些酶参与 RNA 聚合酶 I 沉默核糖体 RNA 转录。据信 BAZ2B 参与调节核小体沿线性 DNA 的动员 . BAZ2-ICR 以 109 nM (ITC) 的 KD 与 BAZ2A 结合,以 170 nM (ITC) 的 KD 与 BAZ2B 结合。 BAZ2-ICR 还显示在 BAZ2A FRAP 测定中以 1 μM 进行光漂白 (FRAP) 恢复后的荧光恢复加速。
 

特点和优势

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
BAZ2-ICR is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
 

其他说明

BAZ2-ICR has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the BAZ2-ICR probe summary on the Chemical Probes Portal website.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 10 mg/mL, clear

储存温度

2-8°C

SMILES string

CN(N=C1)C=C1CCN2C=NC(C3=CN(C)N=C3)=C2C4=CC=C(C#N)C=C4

InChI

1S/C20H19N7/c1-25-12-16(10-23-25)7-8-27-14-22-19(18-11-24-26(2)13-18)20(27)17-5-3-15(9-21)4-6-17/h3-6,10-14H,7-8H2,1-2H3

InChI key

RRZVGDGTWNQAPW-UHFFFAOYSA-N

 

安全信息

象形图

Skull and crossbones

警示用语:

Danger

危险声明

预防措施声明

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16