BAY-598 is a potent, peptide-competitive chemical probe for SET and MYND domain-containing protein 2 (SMYD2), a lysine methyl transferase inhibitor that dimethylates histone H3K36 and methylates histone H3K4. SMYD2 also methylates Lys-370 of p53, leading to decreased DNA-binding activity. SMYD2 is over-expressed in several cancers with poor prognosis. BAY-598 inhibits
in vitro methylation of p53K370 with an IC
50 value of 27 nM and in cells with an IC
50 value < 1 μM. BAY-598 is more than 100-fold selective over other histone methyltransferases and non-epigenetic targets. BAY-598 can be used with
in vivo experiments. For full characterization details, please visit the
BAY-598 probe summary on the Structural Genomics Consortium (SGC) website.
BAY-369 is the negative control for the active probe, BAY-598. To request a sample of the negative control from the SGC,
click here.
To learn about other SGC chemical probes for epigenetic targets, visit
sigma.com/sgc
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N-甲基-D-葡胺 [葡甲胺]，N-Methyl-D-glucamine；Pharmaceutical Secondary Standard; Certified Reference Material![图片 (-)-香芹醇 [顺反异构体混合物]，(−)-Carveol；analytical standard, ≥98% (sum of isomers, GC)](https://www.bszh.cn/images/thumbs/0012601_-carveolanalytical-standard-98-sum-of-isomers-gc_32.jpeg "显示明细 (-)-香芹醇 [顺反异构体混合物]，(−)-Carveol；analytical standard, ≥98% (sum of isomers, GC)")
(-)-香芹醇 [顺反异构体混合物]，(−)-Carveol；analytical standard, ≥98% (sum of isomers, GC)![图片 介藜芦胺 [蒜黎芦碱]，Jervine；≥98% (HPLC), powder](https://www.bszh.cn/images/thumbs/0012096_-jervine98-hplc-powder_32.jpeg "显示明细 介藜芦胺 [蒜黎芦碱]，Jervine；≥98% (HPLC), powder")
介藜芦胺 [蒜黎芦碱]，Jervine；≥98% (HPLC), powder
苏丹红7B，Sudan Red 7B；for microscopy (Bot., Hist.)
5-(Fmoc-氨基)-1-戊醇，5-(Fmoc-amino)-1-pentanol；≥98.0% (HPLC)
1,10-二氨基癸烷，1,10-Diaminodecane；97%