sevenspikes.themes.common.filters
sevenspikes.themes.common.closemenu

Bay 11-7085,≥98% (HPLC), solid

别名:(E)-3-(4-叔丁基苯基)-2-丙烯腈;Bay-117085;(E)-3-(4-t-Butylphenylsulfonyl)-2-propenenitrile

CAS号 196309-76-9 经验分子式(希尔表示法) C13H15NO2S 分子量 249.33 MDL number MFCD01862602 PubChem Substance ID 24278273 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): B5681
CAS号: 196309-76-9
MDL号: MFCD01862602
增值税发票 √ 免费送货 √ 订货电话:010-68689484
¥1,591.65

产品描述

一种TNFα诱导的IκBα磷酸化逆抑制剂,IC50:10μM。

Application

Bay 11-7085 has been used as:
•  nuclear factor-κB inhibitor in Panc-1 cells[4], macrophages[7]
• inhibitory κB kinase IKK inhibitor in human astrocytoma cells U87MGs[5]
•  phospho-p65 inhibitor human monocyte cell line THP-1[6]

包装

10 mg in glass bottle

Biochem/physiol Actions

Bay 11-7085 inactivates peroxisome proliferator-activated receptors γ (PPAR-γ) and increases the microtubule-associated proteins 1A/1B light chain 3B (LC3B), a marker of autophagy resulting in apoptosis in human synovial fibroblasts.[1] It promotes apoptosis in pancreatic carcinoma and may serve as radiotherapy-sensitizing drug.[2] BAY 11-7085 decreases B-cell lymphoma 2 (Bcl-2) by inhibiting pI-κBα (inhibitor of nuclear factor κ B kinase subunit α[3]

抑制 NF-κB 激活 ICAM-1、VCAM-1、E-选择蛋白、IL-6 和 IL-8 的表达。

Features and Benefits

该化合物也是 Sigma 药理活性化合物库(LOPAC®1280)的一部分,该库是一个生物学注释的高品质、可即时筛选化合物的集合。点击此处了解更多信息。

法律信息

LOPAC 为以下机构的注册商标: Sigma-Aldrich Co. LLC

性质

Quality Level  100
assay  ≥98% (HPLC)
form  solid
color  white
solubility  DMSO: soluble >25 mg/mL
 H2O: insoluble
SMILES string  CC(C)(C)c1ccc(cc1)S(=O)(=O)\C=C\C#N
InChI  1S/C13H15NO2S/c1-13(2,3)11-5-7-12(8-6-11)17(15,16)10-4-9-14/h4-8,10H,1-3H3/b10-4+
InChI key  VHKZGNPOHPFPER-ONNFQVAWSA-N
Gene Information  human ... NFKB1(4790)


安全信息

个人防护装备 EyeshieldsGlovestype N95 (US)
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32