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APN-COCI;≥95%

别名:4-(氰乙炔基)苯甲酰氯;4-(cyanoethynyl)benzoyl chloride; Empirical Formula (Hill Notation): C10H4ClNO 分子量: 189.60 PubChem化学物质编号: 329768747
制造商品牌: Sigma-Aldrich
货号(SKU): 807745
CAS号: 1644038-91-4
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¥1,513.63

说明

应用

APN-COCl is a bifunctional reagent appropriate for the introduction of APN function.
 

其他说明

The coupling between an amine and APN-COCl should be performed in dry organic solvents (e.g. THF) in the presence of a base (e.g. TEA). The resulting conjugate can be readily coupled with thiol-containing biomolecules using the following protocol:
  • Dissolve the protein in the appropriate buffer with pH 6.5-9.0 (e.g. PBS) at 1-10 mg/mL concentration.
  • Apply the appropriate amount of the stock solution of the APN-labeled molecule (1-5 molar eq. per free cysteine residue).
  • Incubate at room temperature for 2 hours.
If necessary, purify the protein conjugate using size exclusion chromatography or ultrafiltration.
 
 

属性

形式

powder

质量水平

reaction suitability

reagent type: cross-linking reagent

储存温度

2-8°C

SMILES string

N#CC#CC1=CC=C(C(Cl)=O)C=C1

InChI

1S/C10H4ClNO/c11-10(13)9-5-3-8(4-6-9)2-1-7-12/h3-6H

InChI key

OWNJCJKKKZXTIX-UHFFFAOYSA-N

 

安全信息

象形图

CorrosionExclamation mark

警示用语:

Danger

危险声明

危险分类

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B

储存分类代码

8A - Combustible, corrosive hazardous materials

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32