General description
一种muscarinic/σ1配体。
Anavex2-73 is a muscarinic/σ1 ligand. ANAVEX2-73 (0.01-3.0 mg/kg i.p.) alleviated the scopolamine- and dizocilpine-induced learning impairments. ANAVEX2-73 (300 μg/kg) also reversed the learning deficits in mice injected with Aβ(25-35) peptide, a non-transgenic Alzheimer's disease model. The neuroprotective activity of ANAVEX2-73, its mixed cholinergic/σ(1) activity, its low active dose range and its long duration of action together reinforce its therapeutic potential in Alzheimer's disease.
Anavex2-73是毒蕈碱/σ1配体。 ANAVEX2-73（0.01-3.0 mg / kg i.p.）缓解了东pol碱和地佐西平引起的学习障碍。 ANAVEX2-73（300μg/ kg）还逆转了注射Aβ（25-35）肽（一种非转基因的阿尔茨海默氏病模型）的小鼠的学习缺陷。 ANAVEX2-73的神经保护活性，其胆碱能/σ（1）混合活性，低活性剂量范围和长作用时间共同增强了其在阿尔茨海默氏病中的治疗潜力。
性质
| Iupac Name | 1-(2,2-diphenyltetrahydrofuran-3-yl)-N,N-dimethylmethanamine hydrochloride |
| Inchi Code | 1S/C19H23NO.ClH/c1-20(2)15-18-13-14-21-19(18,16-9-5-3-6-10-16)17-11-7-4-8-12-17;/h3-12,18H,13-15H2,1-2H3;1H |
| Inchi Key | FEQOLYDPQKHFTD-UHFFFAOYSA-N |
安全信息
RIDADR NONH for all modes of transport
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