A cell-permeable inhibitor of lipopolysaccaride (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Blocks LPS-induced tyrosine phosphorylation of a p42MAPK protein substrate.
A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Blocks LPS-induced tyrosine phosphorylation of a p42MAPK/ERK2 protein substrate. Reduces the expression of iNOS and COX-2 in lungs of rats treated with carrageenan. Blocks glucocorticoid-induced COX-2 activity in human amnion cells (IC50 = 15.38 µM).
5 mg，25mg，100mg in Alu drum
Cell permeable: yes
Product does not compete with ATP.
Target IC50: 15.38 µM in blocking glucocorticoid-induced COX-2 activity in human amnion cells
Toxicity: Toxic (F)
Cuzzocrea, S., et al. 2000. Am. J. Pathol.157, 145.
Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol.77, 138.
Kan, H., et al. 1996. Mol. Pharmacol.50, 1139.
Novogrodsky, A., et al. 1994. Science264, 1319.
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|assay ||≥99% (HPLC)|
|storage condition ||OK to freeze|
| ||protect from light|
|storage conditions ||-20℃|
|solubility ||DMSO: 5 mg/mL|
| ||DMF: soluble|
|shipped in ||ambient|
|InChI key ||DUQADSPERJRQBW-UHFFFAOYSA-N|