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AG126,≥99% (HPLC)

别名:AG-126;AG 126;2-(3-羟基-4-硝基苯亚甲基)丙二腈;α-Cyano-(3-hydroxy-4-nitro)cinnamonitrile

CAS:118409-62-4;分子式:C10H5N3O3;分子量:215.17
制造商品牌: BSZH 科学公司
货号(SKU): A06149
CAS号: 118409-62-4
MDL号: MFCD00236448
增值税发票 √ 免费送货 √ 订货电话:010-68689484
¥20,483

产品描述

一种选择性的ERK1(P44)和ERK2(P42)在25-50μm的磷酸化的抑制剂。

General description

A cell-permeable inhibitor of lipopolysaccaride (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Blocks LPS-induced tyrosine phosphorylation of a p42MAPK protein substrate.

A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Blocks LPS-induced tyrosine phosphorylation of a p42MAPK/ERK2 protein substrate. Reduces the expression of iNOS and COX-2 in lungs of rats treated with carrageenan. Blocks glucocorticoid-induced COX-2 activity in human amnion cells (IC50 = 15.38 µM).

包装

5 mg,25mg,100mg in Alu drum

Biochem/physiol Actions

Cell permeable: yes

Primary Target
COX-2 activity

Product does not compete with ATP.

Reversible: no

Target IC50: 15.38 µM in blocking glucocorticoid-induced COX-2 activity in human amnion cells

Warning

Toxicity: Toxic (F)

Other Notes

Cuzzocrea, S., et al. 2000. Am. J. Pathol.157, 145.
Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol.77, 138.
Kan, H., et al. 1996. Mol. Pharmacol.50, 1139.
Novogrodsky, A., et al. 1994. Science264, 1319.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

性质

assay  ≥99% (HPLC)
form  solid
storage condition  OK to freeze
 protect from light
storage conditions  -20℃
color  yellow
solubility  DMSO: 5 mg/mL
 DMF: soluble
shipped in  ambient
InChI  1S/C10H5N3O3/c11-5-8(6-12)3-7-1-2-9(13(15)16)10(14)4-7/h1-4,14H
InChI key  DUQADSPERJRQBW-UHFFFAOYSA-N


安全信息

风险声明 (欧洲) 23/24/25
安全声明 (欧洲) 26-36
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 55 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 8 | 香港与北京 ≥ 10