Affinity chromatography resin designed for the purification of adeno-associated virus (AAV). Capto AVB is based on a rigid base matrix, delivering excellent pressure-flow properties to AAV production.
设计用于纯化腺相关病毒 (AAV) 的亲和层析树脂。 Capto AVB 基于刚性基体，为 AAV 生产提供出色的压力流动特性。
- Efficient, industrial-scale purification of AAV of several subclasses by affinity chromatography.
- Non-mammalian derived product to reduce regulatory concerns.
- High selectivity and excellent scalability.
The possibility to run at higher flow rates and bed heights increases flexibility in process design and allows for an increased productivity.
|Parameter||Capto AVB, 1 L|
|Ligand||Recombinant protein (Mr 14 000) produced in Saccharomyces cerevisiae. Binds AAV of subclasses 1, 2, 3, and 5 |
|Matrix||Highly cross-linked agarose, spherical |
|Particle Size1||50 μm |
|pH stability, operational2||3 to 10 |
|pH stability, CIP3||2 to 12 |
|Flow velocity4||Min. 220 cm/h |
|Storage||20% ethanol at temperatures between 4°C and 8°C. |
|Chemical stability||Stable in commonly used aqueous buffers used in purification of AAV. |
|Binding capacity/mL chromatography resin||Typically, > 1012 genome copies/mL of chromatography resin |
|Pack size||1 L |