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A-395N,≥98% (HPLC)

别名:(3S,4R)-{1-Benzyl-4-[4-(4-methanesulfonyl-piperazin-1-yl)-phenyl]-pyrrolidin-3-yl}-dimethyl-amine, (3S,4R)-1-Benzyl-N,N-dimethyl-4-(4-(4-(methylsulfonyl)piperazin-1-yl)phenyl)pyrrolidin-3-amine

Empirical Formula (Hill Notation): C24H34N4O2S 分子量: 442.62
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML1879
增值税发票 √ 免费送货 √ 订货电话:010-68689484
€150.80

说明

生化/生理作用

A-395N is a control probe for A-395, which is a chemical probe for polycomb protein EED. A-395 is a potent and selective chemical probe for the polycomb protein EED (embryonic ectoderm development), an essential component of Polycomb repressive complex 2 (PRC2), involved in transcriptional repression through methylation of histone H3K27. A-395N is structurally similar, but exhibits no activity in the biochemical and cellular assays, so is an ideal control compound. For characterization details of the active probe, A-395, please visit the A-395 probe summary on the Structural Genomics Consortium (SGC) website.

A-395, the active enantiomer, is available from Sigma. To learn more about and purchase A-395, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
 
A-395N 是 A-395 的对照探针,A-395 是多梳蛋白 EED 的化学探针。 A-395 是多梳蛋白 EED(胚胎外胚层发育)的有效选择性化学探针,是多梳抑制复合物 2 (PRC2) 的重要组成部分,通过组蛋白 H3K27 的甲基化参与转录抑制。 A-395N 结构相似,但在生化和细胞分析中没有活性,因此是理想的对照化合物。
 

特点和优势

A-395N is a negative control for A-395, an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

旋光性

[α]/D +1.0 to +3.0°, c = 1 in chloroform-d

颜色

white to beige

溶解性

DMSO: 10 mg/mL, clear

储存温度

2-8°C

 

安全信息

象形图

Skull and crossbones

警示用语:

Danger

危险声明

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16