A-366，≥98% (HPLC)

5, 25 mg in glass bottle

 

A-366 is an SGC chemical probe for G9a/GLP, developed in collaboration with Abbvie. A-366 is a potent, selective inhibitor of the histone methyltransferase G9a. The IC₅₀ values for G9a inhbition in enzymatic and cell based assays are 3.3 and approximately 3 μM, respectively. A-366 has little or no detectable activity against a panel of 21 other methyltransferases. For full characterization details, please visit the A-366 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

 

A-366 是与 Abbvie 合作开发的 G9a/GLP 的 SGC 化学探针。 A-366 是一种有效的选择性组蛋白甲基转移酶 G9a 抑制剂。 G9a 抑制在酶促和基于细胞的测定中的 IC50 值分别为 3.3 和约 3 μM。 A-366 对一组 21 种其他甲基转移酶几乎没有或没有可检测的活性。

 

A-366 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

 

A-366 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the A-366 probe summary on the Chemical Probes Portal website.