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A-366,≥98% (HPLC)

别名:5′-Methoxy-6′-[3-(1-pyrrolidinyl)propoxy]-spiro[cyclobutane-1,3′-[3H]indol]-2′-amine;5'-甲氧基-6'-(3-(吡咯烷-1-基)丙氧基)螺[环丁烷-1,3'-吲哚]-2'-胺

Empirical Formula (Hill Notation): C19H27N3O2 CAS号: 1527503-11-2 分子量: 329.44 MDL编号: MFCD28133403 PubChem化学物质编号: 329825857 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML1410
CAS号: 1527503-11-2
MDL号: MFCD28133403
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€150.80

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

A-366 is an SGC chemical probe for G9a/GLP, developed in collaboration with Abbvie. A-366 is a potent, selective inhibitor of the histone methyltransferase G9a. The IC50 values for G9a inhbition in enzymatic and cell based assays are 3.3 and approximately 3 μM, respectively. A-366 has little or no detectable activity against a panel of 21 other methyltransferases. For full characterization details, please visit the A-366 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
 
A-366 是与 Abbvie 合作开发的 G9a/GLP 的 SGC 化学探针。 A-366 是一种有效的选择性组蛋白甲基转移酶 G9a 抑制剂。 G9a 抑制在酶促和基于细胞的测定中的 IC50 值分别为 3.3 和约 3 μM。 A-366 对一组 21 种其他甲基转移酶几乎没有或没有可检测的活性。
 

特点和优势

A-366 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
 

其他说明

A-366 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the A-366 probe summary on the Chemical Probes Portal website.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 10 mg/mL, clear

储存温度

2-8°C

SMILES string

NC1=NC2=CC(OCCCN3CCCC3)=C(OC)C=C2C14CCC4

InChI

1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21)

InChI key

BKCDJTRMYWSXMC-UHFFFAOYSA-N

 

安全信息

象形图

Environment

警示用语:

Warning

危险声明

预防措施声明

RIDADR

UN 3077 9 / PGIII

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16