7-乙基-10-羟基喜树碱，7-Ethyl-10-hydroxycamptothecin [SN-38]；≥98% (HPLC), powder

图片 7-乙基-10-羟基喜树碱，7-Ethyl-10-hydroxycamptothecin [SN-38]；≥98% (HPLC), powder
别名：(4S)-4,11-二乙基-4,9-二羟基-1H-吡喃酮[3′,4′:6,7]中氮茚[1,2-b]喹啉-3,14(4H,12H)二酮；伊立替康相关化合物B；Irinotecan Related Compound B；7-乙基-10-羟基喜树脂；SN-38, 是拓扑异构酶I抑制剂伊立替康的活性代谢产物, SN-38 (NK012) 抑制DNA合成和RNA 合成的IC50分别为0.077 和 1.3 μM

Empirical Formula (Hill Notation): C22H20N2O5 CAS号: 86639-52-3 分子量: 392.40 MDL编号: MFCD00871873 PubChem化学物质编号: 329815105 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: H0165
CAS号: 86639-52-3
MDL号: MFCD00871873
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说明

应用

7-Ethyl-10-hydroxycamptothecin has been used:
  • to inhibit enterovirus 71 (EV71) (H) infection[1]
  • to screen the chemosensitivity of pancreatic adenocarcinoma cells[2]
  • as a chemical to study its ability to reverse multidrug resistance (MDR), due to ATP binding cassette (ABC) transporters[3]

生化/生理作用

Active metabolite of irinotecan. Inhibitor of topoisomerase I.. Gene expression analysis of colon cancer cell lines treated with SN-38 showed differential effects: the majority of affected genes were down-regulated (including, most strongly, genes related to receptor and kinase activity, signal transduction, apoptosis, RNA processing, protein metabolism and transport, cell cycle and transcription. Some of the up-regulated genes were involved in apoptosis, transcription, development and differentiation.
 
 

属性

生物来源

Artemisia annua

质量水平

200

测定

≥98% (HPLC)

形式

powder

溶解性

DMSO: 1 mg/mL

储存温度

−20°C

SMILES string

OC1=CC2=C(CC)C(C3)=C(N=C2C=C1)C(N3C4=O)=CC5=C4COC([C@]5(O)CC)=O

InChI

1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1

InChI key

FJHBVJOVLFPMQE-QFIPXVFZSA-N

 

安全信息

象形图

Exclamation markHealth hazard
GHS07,GHS08

警示用语：

Danger

危险分类

Acute Tox. 4 Oral - Repr. 1B - STOT RE 1

靶器官

Gastro-intestinal system

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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