7-乙基-10-羟基喜树碱，7-Ethyl-10-hydroxycamptothecin [SN-38]；Pharmaceutical Secondary Standard; Certified Reference Material

别名：伊立替康相关化合物B标准品；Irinotecan Related Compound B；(4S)-4,11-二乙基-4,9-二羟基-1H-吡喃酮[3′,4′:6,7]中氮茚[1,2-b]喹啉-3,14(4H,12H)二酮；(4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione；7-乙基-10-羟基喜树脂；SN-38, 是拓扑异构酶I抑制剂伊立替康的活性代谢产物, SN-38 (NK012) 抑制DNA合成和RNA 合成的IC50分别为0.077 和 1.3 μM

Empirical Formula (Hill Notation): C22H20N2O5 CAS号: 86639-52-3 分子量: 392.40 MDL编号: MFCD00871873

制造商品牌: 默克色谱科 Supelco , 西格玛 Sigma-Aldrich

货号（SKU）: PHR2718

CAS号: 86639-52-3

MDL号: MFCD00871873

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目录价.SKU-Variant

20mg

¥5,650.26

数量:

说明

一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

属性

等级

certified reference material
pharmaceutical secondary standard

Agency

traceable to USP 1347631

形式

solid

CofA

current certificate can be downloaded

储存温度

2-8°C

SMILES string

CCc1c2CN3C(=O)C4=C(C=C3c2nc5ccc(O)cc15)[C@@](O)(CC)C(=O)OC4

InChI

1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1

InChI key

FJHBVJOVLFPMQE-QFIPXVFZSA-N

安全信息

象形图

GHS07,GHS08

警示用语：

Danger

危险声明

H302 - H360D - H372

预防措施声明

P201 - P202 - P260 - P264 - P301 + P312 - P308 + P313

危险分类

Acute Tox. 4 Oral - Repr. 1B - STOT RE 1

靶器官

Gastro-intestinal system

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格

属性名称	属性值
储存温度 Storage temp.	2-8°C冷藏
全球实时库存 Availability √	美国St. Louis ≥ 99 \| 欧洲Eur. ≥ 10 \| 東京Tokyo ≥ 22 \| 香港与北京 ≥ 32

商品标签 [tags]

sn-38 (2)