5,5-二苯基海因钠盐 [苯妥英钠]，5,5-Diphenylhydantoin sodium salt；≥99%

图片 5,5-二苯基海因钠盐 [苯妥英钠]，5,5-Diphenylhydantoin sodium salt；≥99%
别名：5,5-联苯基乙内酰脲；5,5-二苯乙内酰脲钠；苯妥英；5,5-Diphenyl-2,4-imidazolidinedione；Phenytoin；Phenytoin sodium

线性分子式: C15H11N2O2Na CAS号: 630-93-3 分子量: 274.25 EC 号: 211-148-2 MDL编号: MFCD00069674 PubChem化学物质编号: 24277707 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: D4505
CAS号: 630-93-3
MDL号: MFCD00069674
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

说明

5,5-二苯基乙内酰脲钠盐是苯妥英钠的衍生物。5,5-二苯基乙内酰脲用于治疗癫痫并具有抗癫痫活性。它通过阻断钠通道和调节神经元的兴奋来发挥作用。然而，副作用包括牙齿周围的牙龈组织增生和过度生长。它通过调节生长因子促进神经干细胞的增殖。二苯乙内酰脲具有毒性，可诱导培养的小脑颗粒神经元凋亡。

一般描述

5,5-Diphenylhydantoin sodium salt is a derivative of phenytoin. 5,5-Diphenylhydantoin is used for treating epilepsy and has antiepileptic activity. It functions by blocking the sodium channels and modulates excitation of neurons. However, the side effects include hypertrichosis and overgrowth of gum tissue around the teeth. It promotes proliferation of the neural stem cells by modulating growth factors. Diphenylhydantoin is toxic and induces apoptosis in cultured cerebellar granule neurons.
 

应用

5,5-Diphenylhydantoin sodium salt has been used:
  • in the cream preparation for treating burn wounds
  • in seizure behavior testing as an anticonvulsant in Drosophila
  • in in vivo embryo toxicity test in mouse embryonic stem cells

生化/生理作用

减少癫痫大发作的发生率；可能通过 Na+、K+ 和 Ca2+ 通道的影响而稳定可兴奋膜。
 

特点和优势

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
 
 

属性

质量水平

200

测定

≥99%

形式

powder

溶解性

aqueous base: soluble

SMILES string

[Na]N1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3

InChI

1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1

InChI key

FJPYVLNWWICYDW-UHFFFAOYSA-M

Gene Information

human ... CNR1(1268) , CNR2(1269) , CYP2C9(1559) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)
rat ... Faah(29347) , Scn1a(81574) , Scnn1g(24768) , Slc6a1(79212)

 

安全信息

象形图

Exclamation markHealth hazard
GHS07,GHS08

警示用语：

Warning

危险声明

H302 - H317 - H361

危险分类

Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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