sevenspikes.themes.common.filters
sevenspikes.themes.common.closemenu

4-(2-氨乙基)苯磺酰氟盐酸盐,4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride [AEBSF];analytical standard, ≥95.0% (HPLC)

CAS号 30827-99-7 经验分子式(希尔表示法) C8H10FNO2S · HCl 分子量 239.69 Beilstein/REAXYS Number 7604627 MDL number MFCD00132962 PubChem Substance ID 329767025 NACRES NA.24
货号(SKU): 76307
CAS号: 30827-99-7
MDL号: MFCD00132962
增值税发票 √ 免费送货 √ 订货电话:010-68689484
¥1,460.95

产品描述

General description

Pefabloc® SC is a potent, nontoxic and relatively easy to use, irreversible serine proteinase inhibitor. It is reported to efficiently inhibit the platelet activating factor (PAF)-degrading acetylhydrolase (acetylhydrolase) in both humans and rats.[5]

Pefabloc® SC是一种胰蛋白酶抑制剂,可用于合成其精氨酸样类似物4-(2-胍基乙基)苯磺酰氟。[4]

Application

Pefabloc® SC may be used as an analytical standard in determining the native oligomeric state and substrate specificity of rat NTPDase1 and NTPDase2 after heterologous expression in Xenopus oocytes.[6] It may also be used as an esterase inhibitor, which is added to the whole blood to improve the stability of ciclesonide for the determination of ciclesonide (CIC) and its active metabolite, desisobutyryl-ciclesonide (des-CIC), in human plasma using liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometric (LC-APCI-MS/MS) method.[7]

有关合适的仪器技术的更多信息,请参阅产品′的分析证书。想要获得更多支持,请联系技术服务部。

建议使用浓度为 0.1 至 1mM。

Biochem/physiol Actions

不可逆的丝氨酸蛋白酶抑制剂。抑制常数与 PMSF 和 DFP 的抑制常数相似。AEBSF 可以抑制胰蛋白酶、糜蛋白酶、纤溶酶、激肽释放酶和凝血酶。作为 PMSF 和 DFP 的替代物,AEBSF 的毒性更低、水溶性和水溶液稳定性更好。AEBSF 已用于细胞培养,使用浓度可达 0.25mM。

Other Notes

有效且不可逆的丝氨酸蛋白酶抑制剂;与PMSF不同,它是水溶性且无毒的[2][1];不受白蛋白影响[3]

法律信息

Pefabloc 为以下机构的注册商标: Pentapharm

性质

Quality Level200
gradeanalytical standard
assay≥95.0% (HPLC)
formpowder or crystals
shelf life5 yr
application(s)HPLC: suitable
gas chromatography (GC): suitable
Featured IndustryForensics and Toxicology
Pharmaceutical (small molecule)
formatneat
storage temp.2-8°C
SMILES stringFS(C1=CC=C(CCN)C=C1)(=O)=O.[H]Cl
InChI1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
InChI keyWRDABNWSWOHGMS-UHFFFAOYSA-N


安全信息

符号
GHS07  GHS07
信号词 Warning
危害声明 H315 - H319
危害码 (欧洲) C
风险声明 (欧洲) 34
安全声明 (欧洲) 26-36/37/39-45
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16
商品标签