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3-TYP,≥99% (HPLC)

别名:3-(1H-1,2,3-三唑-4-基)吡啶;3-(1H-1,2,3-triazol-4-yl) pyridine

CAS:120241-79-4;分子式:C7H6N4;分子量:146.15;MDL:MFCD25956467
制造商品牌: BSZH 科学公司
货号(SKU): S06097
CAS号: 120241-79-4
MDL号: MFCD25956467
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¥822.00

产品描述

产品可溶于DMSO(25mg/mL)、乙醇和水

Application

一种选择性的SIRT3抑制剂,IC50:16 nM。有比对SIRT1和SIRT2更强的选择性,对其IC50值为88 nM 和 92 nM。

In Vitro:3-TYP inhibits melatonin-enhanced SIRT3 activity but does not affect SIRT3 protein expression. 3-TYP pretreatment reverses the protective effects of melatonin on cadmium (Cd)-induced mitochondrial-derived O2?? production and autophagic cell death. 3-TYP significantly attenuates melatonin-induced increases in deacetylated-SOD2 expression and SOD2 activity in HepG2 cells exposed to Cd.
In Vivo:3-TYP (50 mg/kg, i.p.) does not significantly influence the LVEF, LVFS, infarct size, serum LDH levels, apoptosis, and oxidative stress compared with those of the Sham group. Moreover, 3-TYP has little effect on gp91phox, Nrf2, NQO 1, Bax, Bcl-2, Caspase-3, and cleaved Caspase-3 expression levels, compared with the Sham group. 3-TYP significantly decreases SIRT3 activity and increases the acetylation of SOD2 compared with that in the control group, without influencing SIRT3 expression. 3-TYP attenuates the cardioprotective effects of melatonin by decreasing the LVEF and LVFS after 24 hour of reperfusion. 3-TYP also increases the infarct size, serum LDH levels, and apoptotic ratio compared with those in the IR+Mel group.

体外:3-TYP抑制褪黑激素增强的SIRT3活性,但不影响SIRT3蛋白表达。 3-TYP预处理可逆转褪黑素对镉(Cd)诱导的线粒体来源的O2的保护作用。产生和自噬细胞死亡。 3-TYP显着减弱褪黑素诱导的Cd暴露的HepG2细胞中脱乙酰化SOD2表达和SOD2活性的增加。
体内:与假手术组相比,3-TYP(50 mg / kg,腹膜内)对LVEF,LVFS,梗死面积,血清LDH水平,细胞凋亡和氧化应激没有显着影响。此外,与Sham组相比,3-TYP对gp91phox,Nrf2,NQO 1,Bax,Bcl-2,Caspase-3和裂解的Caspase-3表达水平几乎没有影响。与对照组相比,3-TYP显着降低SIRT3活性并增加SOD2的乙酰化,而不会影响SIRT3的表达。 3-TYP在再灌注24小时后通过降低LVEF和LVFS来减弱褪黑激素的心脏保护作用。与IR + Mel组相比,3-TYP还增加了梗塞面积,血清LDH水平和细胞凋亡率。

性质

Iupac Name3-(1H-1,2,3-triazol-4-yl)pyridine
Inchi Code1S/C7H6N4/c1-2-6(4-8-3-1)7-5-9-11-10-7/h1-5H,(H,9,10,11)
Inchi KeyVYXFEFOIYPNBFK-UHFFFAOYSA-N


安全信息

符号 
GHS07  GHS07
信号词 Warning
危害声明 H302
警示性声明 P301 + P312 + P330
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32