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3-(4-溴苯基)-3-(三氟甲基)-3H-双吖丙啶,3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine;≥95%

别名:Probe building block for photoaffinity labeling, Suzuki-Miyaura-compatible multifunctional photo probe building block, Trifluoromethyl diazirine aryl bromide

Empirical Formula (Hill Notation): C8H4BrF3N2 CAS号: 952143-02-1 分子量: 265.03
制造商品牌: Sigma-Aldrich
货号(SKU): 906298
CAS号: 952143-02-1
技术支持 √ 增值税发票 √ 免费送货 √ 质量保障 √
¥1,518.97

说明

应用

3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine is a Suzuki-Miyaura (S−M)-compatible building block tailored for the design of photoaffinity probes (PAPs). Photoaffinity labeling (PAL) is of growing interest in chemical biology and drug discovery research for use in protein profiling; covalent inhibitors; protein-protein interactions and complexes; and target engagement, identification, or validation studies. Diazirines are desirable photoactivable groups for chemical probes; however, their installation is not always straightforward. In response, diazirine-tolerant S-M coupling conditions were developed by Ichiishi, et al, using 3-(4-bromophenyl)-3-(trifluoromethyl)-3H-diazirine and shown to be efficient and scalable with minimal perturbation of the diazirine.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)
 

其他说明

 
 

属性

检测方案

≥95%

形式

liquid

reaction suitability

reagent type: cross-linking reagent

储存温度

2-8°C

SMILES string

BrC1=CC=C(C2(N=N2)C(F)(F)F)C=C1

 

安全信息

储存分类代码

10 - Combustible liquids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 55 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 8 | 香港与北京 ≥ 10