Application
3-甲基腺嘌呤(3-MA)用于抑制和研究多种条件下自噬(溶酶体自我降解)和细胞凋亡的机制。3-MA可通过抑制III型磷脂酰肌醇3-激酶(PI-3K)阻断自噬体的形成来对自噬进行抑制。 3-MA通常以5 mM的浓度用作自噬抑制剂。Standard for detection of nucleic acid methylation during carcinogenesis.
包装
100, 500 mg in poly bottle
Preparation Note
This product is soluble in DMF (10 mg/mL; may require gentle heating). It is also soluble in water, 95% ethanol, or 1 N NaOH at 30 mg/mL with heating, but upon cooling, the product precipitates from solution. Solutions of 3-MA may be prepared in DMSO at 100 mM.
性质
Quality Level | 300 |
assay | ≥99% (HPLC) |
form | powder |
mp | ~300 °C (dec.) (lit.) |
solubility | DMF: 9.80-10.20 mg/mL, clear, colorless to light yellow |
SMILES string | Cn1cnc(N)c2ncnc12 |
InChI | 1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3InChI key | FSASIHFSFGAIJM-UHFFFAOYSA-N | |
安全信息
RIDADR NONH for all modes of transport