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3-甲基腺嘌呤,3-Methyladenine [3-MA];autophagy inhibitor, ≥99% (HPLC)

6-氨基-3-甲基嘌呤;6-Amino-3-methylpurine;CAS号 5142-23-4 经验分子式(希尔表示法) C6H7N5 分子量 149.15 Beilstein/REAXYS Number 146087 EINECS 编号 225-908-6 MDL number MFCD00010531 PubChem Substance ID 24897326 NACRES NA.51
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): M9281
CAS号: 5142-23-4
MDL号: MFCD00010531
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HK$2,323.92

产品描述

Application

3-甲基腺嘌呤(3-MA)用于抑制和研究多种条件下自噬(溶酶体自我降解)和细胞凋亡的机制。3-MA可通过抑制III型磷脂酰肌醇3-激酶(PI-3K)阻断自噬体的形成来对自噬进行抑制。 3-MA通常以5 mM的浓度用作自噬抑制剂。

Standard for detection of nucleic acid methylation during carcinogenesis.

包装

100, 500 mg in poly bottle

Preparation Note

This product is soluble in DMF (10 mg/mL; may require gentle heating). It is also soluble in water, 95% ethanol, or 1 N NaOH at 30 mg/mL with heating, but upon cooling, the product precipitates from solution. Solutions of 3-MA may be prepared in DMSO at 100 mM.

性质

Quality Level300
assay≥99% (HPLC)
formpowder
mp~300 °C (dec.) (lit.)
solubilityDMF: 9.80-10.20 mg/mL, clear, colorless to light yellow
SMILES stringCn1cnc(N)c2ncnc12
InChI1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3
InChI keyFSASIHFSFGAIJM-UHFFFAOYSA-N


安全信息

RIDADR NONH for all modes of transport
WGK德国 WGK 3
RTECS AU6520000
商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 190 | 欧洲Eur. ≥ 66 | 東京Tokyo ≥ 82 | 香港与北京 ≥ 55