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3-异丁基-1-甲基黄嘌呤 [IBMX],3-Isobutyl-1-methylxanthine;≥99% (HPLC), powder

别名:1-甲基-3-异丁基黄嘌呤,3,7-二氢-1-甲基-3-(2-甲基丙基)-1H-嘌呤-2,6-二酮,3-异丁基-1-甲基-2,6(1H,3H)-嘌呤二酮,1-Methyl-3-isobutylxanthine 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione,IBMX,MIX

CAS号 28822-58-4 经验分子式(希尔表示法) C10H14N4O2 分子量 222.24 Beilstein/REAXYS Number 247859 EINECS 编号 249-259-3 MDL number MFCD00005584 PubChem Substance ID 24277680 NACRES NA.77
货号(SKU): I5879
CAS号: 28822-58-4
MDL号: MFCD00005584
增值税发票 √ 免费货运 [顺丰 联邦] √
HK$462.43

产品描述

General description

3-isobutyl-1-methylxanthine/IBMX is a non-selective, non-specific inhibitor of cAMP and cGMP phosphodiesterases.[3] IBMX can induce melanogenesis, and can be used as a positive control in melanogenesis research.[2] In oocyte research, IBMX assists in maintaining the germinal vesicle (GV) arrest of prophase I oocytes.

Application

3-Isobutyl-1-methylxanthine has been used:
• in the differentiation of mesenchymal stem cells (MSC)[4]
• as a culture medium supplement for inducing adipogenic differentiation[5]
• as a supplement in Krebs-Ringer buffer with HEPES (KRBH) solution for inducing glucose-stimulated insulin secretion (GSIS)[6]
• in the characterization of adipose-derived mesenchymal stem cells[8]
• in cyclic adenosine monophosphate (cAMP) assay[7]
• in phosphodiesterase (PDE) inhibition[1]

包装

1, 5 g in poly bottle

250 mg in poly tube

100 mg in poly bottle

Biochem/physiol Actions

The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA, leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). IBMX also serves as an adenosine receptor antagonist. IBMX has been shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. IBMX induces calcium release from intracellular stores in sensory neurons.

Features and Benefits

该化合物还作为Sigma药理活性化合物库(LOPAC®1280)中的一部分进行提供,而这是一个具有生物学注释的高品质即用型的筛选化合物集合。 点击此处 以了解更多。

法律信息

LOPAC 为以下机构的注册商标: Sigma-Aldrich Co. LLC

性质

assay≥99% (HPLC)
formpowder
colorwhite to off-white
mp200-201 °C (lit.)
solubilityDMSO: 1 M (with gentle warming)
ethanol: 10 mg/mL
storage temp.−20°C
SMILES stringCC(C)CN1C(=O)N(C)C(=O)c2[nH]cnc12
InChI1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
InChI keyAPIXJSLKIYYUKG-UHFFFAOYSA-N
Gene Informationhuman ... PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
rat ... Adora1(29290), Adora2a(25369)


安全信息

危害码 (欧洲) Xn
风险声明 (欧洲) 22
RIDADR NONH for all modes of transport
WGK德国 3
RTECS ZD8500000
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 300 | 欧洲Eur. ≥ 90 | 東京Tokyo ≥ 36 | 香港与北京 ≥ 99