General description
(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) is an activator of carboxyl group commonly used in peptide synthesis. It also participates in the carboxylic acid esterification.[2] It shows characteristics similar to benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and can be utilized as an alternative to BOP in peptide bond formation.[5]Application
(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) may be used in the following studies:
• As coupling reagent in the preparation strategies for peptide-oligonucleotide conjugates.[3]
• Synthesis of structured pure triacylglycerol (TAG) regioisomers.[2]
• As coupling reagent in the synthesis of a 3,5-pyrazolidinedione on soluble polyethylene glycol (PEG) polymer support.[4]
• Synthesis of herceptin- nanoparticles.[1]BOP 偶联剂类似物,不产生致癌副产物 HMPA。
法律信息
PyBOP 为以下机构的注册商标: Merck KGaA, Darmstadt, Germany