1,2-Dimethoxyethane can be used as a solvent to synthesize:
- Oxazoles from α-acylamino ketones via Robinson-Gabriel reaction.
- 5-Arylhistidines via Suzuki-Miyaura cross-coupling between 5-bromohistidine and arylboronic acids.
- Aryl thioethers via Pd-catalyzed thioetherification of aryl halides with aliphatic and aromatic thiols.