1-Hydroxybenzotriazole is a coupling reagent used to synthesize amides by the condensation reaction between the activated ester/acid and the amino group of protected amino acids. It is also used as a racemization suppressor during peptide synthesis.
1-Hydroxybenzotriazole hydrate can be used as a condensation reagent to prepare:
• Poly-γ-glutamic acid methyl ester from a dimer of γ-glutamic acid.
• Oxadiazoles via cyclo condensation of amidoximes with trifluoroacetic anhydride or benzoic acid derivatives.
|Quality Level ||200|
|assay ||≥97.0% (T)|
|application(s) ||peptide synthesis: suitable|
|impurities ||~12% water|
|mp ||155-158 °C (lit.)|
|solubility ||DMF: 0.1 g/mL, clear|
|SMILES string ||[H]O[H].On1nnc2ccccc12|
|InChI key ||PJUPKRYGDFTMTM-UHFFFAOYSA-N|
RIDADR UN3474 - class 4.1 - PG 1 - 1-Hydroxybenzotriazole, monohydrate