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1-羟基苯并三唑水合物,1-Hydroxybenzotriazole hydrate [HOBt Hydrate];≥97.0% (T)

HOBt一水合物;HOBt水合物;CAS号 123333-53-9 经验分子式(希尔表示法) C6H5N3O · xH2O 分子量 135.12 (anhydrous basis) Beilstein/REAXYS Number 4515 EINECS 编号 219-989-7 PubChem Substance ID 57651485 NACRES NA.22
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): 54802
CAS号: 123333-53-9
MDL号: MFCD00065690
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$46.13

产品描述

General description

1-Hydroxybenzotriazole is a coupling reagent used to synthesize amides by the condensation reaction between the activated ester/acid and the amino group of protected amino acids.[5] It is also used as a racemization suppressor during peptide synthesis.[6]

Application

1-Hydroxybenzotriazole hydrate can be used as a condensation reagent to prepare:
•  Poly-γ-glutamic acid methyl ester from a dimer of γ-glutamic acid.[6]
•  Oxadiazoles via cyclo condensation of amidoximes with trifluoroacetic anhydride or benzoic acid derivatives.[4]

Other Notes

广泛应用于降低碳二亚胺肽偶联外消旋化的添加剂;[1] 肽段的无消旋缩合[3][2]

性质

Quality Level  200
assay  ≥97.0% (T)
application(s)  peptide synthesis: suitable
impurities  ~12% water
mp  155-158 °C (lit.)
solubility  DMF: 0.1 g/mL, clear
SMILES string  [H]O[H].On1nnc2ccccc12
InChI  1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2
InChI key  PJUPKRYGDFTMTM-UHFFFAOYSA-N


安全信息

符号 
信号词 Danger
危害声明 H207 - H319 - H412
补充危害声明 EUH044
危害码 (欧洲) F
风险声明 (欧洲) 1-11-44
安全声明 (欧洲) 26-37-60
RIDADR UN3474 - class 4.1 - PG 1 - 1-Hydroxybenzotriazole, monohydrate
WGK德国 nwg
商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32
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