1-甲基腺苷，1-Methyladenosine [M1A]；≥95% (HPLC)

1-甲基腺苷，也称为M1A，属于称为嘌呤核苷的有机化合物类别。嘌呤核苷是包含连接到核糖基或脱氧核糖基部分的嘌呤碱基的化合物。1-甲基腺苷是一种强碱性化合物（基于其pKa）。通过m6A-CLIP/IP（简称m6A-CLIP）进行的精确m6A定位显示，大多数m6A位于小鼠和人的多个组织/培养细胞中mRNA的最后一个外显子中，并且终止密码子周围的m6A富集是巧合许多终止密码子位于m6A真正富集的最后一个外显子的起点附近。腺苷的甲基化由包含METTL3作为SAM结合亚基的大型m6A甲基转移酶复合物指导。据报道，胰岛素样生长因子2 mRNA结合蛋白1、2和3（IGF2BP1-3）是一类新型的m6A阅读器。

1-Methyladenosine is an RNA modification that arises through distinct processes, including enzymatic catalysis and the alkylation of RNA by specific agents.

 

1-Methyladenosine, a modified nucleoside produced during tRNA processing by methyltransferases, has garnered attention as a potential biomarker for early cancer detection due to its elevated urinary excretion in various cancer forms. Additionally, its presence can be monitored in serum. Moreover, 1-Methyladenosine levels rise during active rheumatoid arthritis, making it a promising indicator for this condition. It finds application in research pertaining to cancer, autoimmune diseases, metabolomics, biomarker discovery and drug discovery studies.