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1α,25-二羟基维生素D3 [骨化三醇],1α,25-Dihydroxyvitamin D3;≥97.0% (HPLC)

别名:1α,25-二羟胆钙化醇;骨化三醇;1α,25-Dihydroxycholecalciferol;Calcitriol

CAS号 32222-06-3 经验分子式(希尔表示法) C27H44O3 分子量 416.64 Beilstein/REAXYS Number 7559394 EINECS 编号 250-963-8 MDL number MFCD00867079 eCl@ss 34058003 PubChem Substance ID 57647688 NACRES NA.79
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): 17936
CAS号: 32222-06-3
MDL号: MFCD00867079
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¥7,549.58

产品描述

一种PKC和VDR的激活剂。

General description

1α,25-Dihydroxyvitamin D3, also referred as calcitriol, is a calcitrophic hormone.[3] It is the most biologically active metabolite of vitamin D produced in proximal tubular cells in the kidney.[2][4]

Application

1α,25-Dihydroxyvitamin D3 has been used to study its effect on transplantation success of human muscle precursor cells (hMPCs) in severe combined immunodeficient (SCID) mice in-vitro.[6]

包装

1 mg in poly bottle

100 μg in poly bottle

Biochem/physiol Actions

1α,25-Dihydroxyvitamin D3 modulates energy metabolism by facilitating various metabolic processes, such as Ca2+ signaling and modulation of glucocorticoids, by affecting adipocyte apoptosis and by regulating the expression and production of multiple cytokines.[3] In addition, it also modulates phosphorus homeostasis through actions in the intestine, kidney and bone.[5] 1α,25-Dihydroxyvitamin D3 exhibits antiproliferative effects and is used as a potent therapeutic for human prostate cancer.[1]

在钙的吸收和沉积中维生素D3的生物活性形式。 1α,25-二羟基维生素D3对细胞分化和增殖具有广泛的作用,并可调节免疫应答和中枢神经系统功能。最近的研究表明,1α,25-二羟基维生素D3可作为抵抗包括前列腺癌和结肠癌在内数种恶性肿瘤的化学预防剂,并显示出了与其他抗癌化合物的协同作用。

包装

无底玻璃瓶。内容物在插入的熔锥内。

性质

Quality Level  200
assay  ≥97.0% (HPLC)
form  crystals
color  white to off-white
storage temp.  −70°C
SMILES string  [H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C)[C@H](C)CCCC(C)(C)O
InChI  1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
InChI key  GMRQFYUYWCNGIN-NKMMMXOESA-N
Gene Information  human ... VDR(7421)


安全信息

商品规格
属性名称属性值
储存温度 Storage temp.-70°C超低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16