(±)-咪康唑硝酸盐 [硝酸咪康唑]，(±)-Miconazole nitrate salt；Pharmaceutical Secondary Standard; Certified Reference Material

图片 (±)-咪康唑硝酸盐 [硝酸咪康唑]，(±)-Miconazole nitrate salt；Pharmaceutical Secondary Standard; Certified Reference Material
别名：硝酸咪康唑标准品；1-(2,4-二氯-β-[(2,4-二氯苄基)氧]苯乙基]咪唑；1-(2,4-Dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole

Empirical Formula (Hill Notation): C18H14Cl4N2O · HNO3 CAS号: 22832-87-7 分子量: 479.14 EC 号: 245-256-6 MDL编号: MFCD00058161 PubChem化学物质编号: 329823180 NACRES: NA.24
制造商品牌: 色谱科 Supelco , 西格玛 Sigma-Aldrich
货号（SKU）: PHR1163
CAS号: 22832-87-7
MDL号: MFCD00058161
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

说明

用于质量控制的制药二级标准，为制药实验室和制造商提供了一种方便且成本效益高的替代方案，以替代内部工作标准的制定。硝酸咪康唑是一种咪唑衍生物，是一种广谱抗真菌药物，用于控制人类和动物的真菌爆发。
硝酸咪康唑可用作通过各种技术测定药物制剂中分析物的药物参考标准。
这些二级标准被认定为合格参考材料。这些适用于多种分析应用，包括但不限于药物释放测试、用于定性和定量分析的药物方法开发、食品和饮料质量控制测试以及其他校准要求。

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Miconazole nitrate is an imidazole derivative and a broad spectrum antifungal drug used in the management of fungal outbreak in humans and veterinary animals.
 

应用

Miconazole nitrate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
 

生化/生理作用

咪康唑与 14-α 相互作用脱甲基酶，一种麦角固醇生物合成所必需的细胞色素 P-450 酶。麦角固醇的抑制导致细胞通透性增加引起细胞内容物渗漏。咪康唑还可能抑制内源性呼吸，与细胞膜中的磷脂相互作用，抑制酵母菌转化为菌丝形式，抑制嘌呤摄取，干扰甘油三酯和磷脂的生物合成。
 

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
 

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Values of analytes vary lot to lot.
 

附注

To see an example of a Certificate of Analysis for this material enter LRAC3325 in the slot below. This is an example certificate only and may not be the lot that you receive.
 
 

属性

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 253
traceable to Ph. Eur. M1900000
traceable to USP 1443500

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES string

ClC1=CC(Cl)=CC=C1C(OCC2=CC=C(Cl)C=C2Cl)CN3C=CN=C3.[O-][N+](O)=O

InChI

1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)

InChI key

MCCACAIVAXEFAL-UHFFFAOYSA-N

 

安全信息

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302 - H317

危险分类

Acute Tox. 4 Oral - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 30 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 30
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