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(±)-α-硫辛酸,(±)-α-Lipoic acid [Lip(S2)];≥98.0%

别名: (±)-1,2-二硫戊环基-3-戊酸,6,8-二巯基辛酸,DL-α-硫辛酸,DL-6,8-硫辛酸,alpha-硫辛酸,5-(1,2-二硫戊环-3-基)戊酸;Lip(S2),(±)-1,2-Dithiolane-3-pentanoic acid, 6,8-Dithiooctanoic acid, DL-α-Lipoic acid, DL-6,8-Thioctic acid

CAS号 1077-28-7 经验分子式(希尔表示法) C8H14O2S2 分子量 206.33 Beilstein/REAXYS Number 81853 EINECS 编号 214-071-2 MDL number MFCD00005474 PubChem Substance ID 57651855 NACRES NA.21
货号(SKU): 62320
CAS号: 1077-28-7
MDL号: MFCD00005474
增值税发票 √ 免费货运 [顺丰 联邦] √
¥1,055.17

产品描述

Application

(±)-α-Lipoic acid has been used in in vitro lipoylation studies and in the pyruvate dehydrogenase complex (PDC)-pyruvate dehydrogenase kinase (PDHK) functional assay. It has also been used to investigate its antioxidative effect on developing cerebellum of rats exposed to arsenic during postnatal period.

包装

5, 25 g in glass bottle

Biochem/physiol Actions

(±)-α-Lipoic acid exhibits direct free radical scavenging property and reduces the increased oxidative stress. In addition, it might also exhibit prooxidant activity. α-Lipoic acid functions as an important prosthetic group in α-keto acid dehydrogenase complexes of the mitochondria. It acts as a potential therapeutic for diabetic patients with distal symmetric polyneuropathy (DSP). α-Lipoic acid is also used in the treatment of energy-impaired and redox unbalanced diseases.

维持酶复合物(例如丙酮酸脱氢酶和甘氨酸脱羧酶的复合物)活性所需的抗氧化剂和辅酶。通过两种或多种酶的作用在细胞内还原外源性硫辛酸。然后,该还原形式通过直接清除自由基、循环利用其他抗氧化剂、增加谷胱甘肽的合成以及调控转录因子(尤其是 NF-κB)的活性而影响许多细胞过程。减少巨噬细胞对髓磷脂的吞噬。

Other Notes

综述

性质

Quality Level200
assay≥98.0% (HPLC)
≥98.0%
ign. residue≤0.1%
loss≤0.2% loss on drying
mp60-62 °C
storage temp.2-8°C
SMILES stringOC(=O)CCCCC1CCSS1
InChI1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)
InChI keyAGBQKNBQESQNJD-UHFFFAOYSA-N
Gene Informationhuman ... ACHE(43), BCHE(590)
rat ... Adra1a(29412), Adra1b(24173), Adra1d(29413)


安全信息

符号
GHS07  GHS07
信号词 Warning
危害声明 H302
个人防护装备 dust mask type N95 (US)EyeshieldsGloves
危害码 (欧洲) Xn
风险声明 (欧洲) 22
RIDADR NONH for all modes of transport
WGK德国 3
RTECS JP1192000
商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 88 | 欧洲Eur. ≥ 126 | 東京Tokyo ≥ 46 | 香港与北京 ≥ 62
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