高车前素，Hispidulin；≥98% (HPLC)

图片 高车前素，Hispidulin；≥98% (HPLC)
别名：5,7-二羟基-2-(4-羟基苯基)-6-甲氧基-4H-1-苯并吡喃-4-酮；4',5,7-三羟基-6-甲氧基黄酮；6-甲氧基芹菜素；丹参素；6-甲基灯盏花素；地那汀；灯盏花素 6-甲醚；5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one, 4′,5,7-Trihydroxy-6-methoxyflavone, 6-Methoxyapigenin, Salvitin, 6-Methylscutellarein, Dinatin, Scutellarein 6-methyl ether

Empirical Formula (Hill Notation): C16H12 O6 CAS号: 1447-88-7 分子量: 300.26 MDL编号: MFCD00143504 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: SML0582
CAS号: 1447-88-7
MDL号: MFCD00143504
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说明

高车前素已被用作校准标准：
在高效液相色谱法 (HPLC) 中定量测定苦瓜中的黄酮类化合物
在液相色谱/电喷雾电离质谱 (LC/ESI-MS) 分析中
在带有二极管阵列检测器的反相高效液相色谱 (HPLC-DAD) 和高效薄层色谱 (HPTLC) 中

高车前素是一种生物活性类黄酮，具有多种作用，包括抗增殖、抗真菌、抗炎、抗氧化和抗癫痫活性。与 EGCG 一样，hispidulin 似乎激活 AMPK 并抑制 PI3K/Akt/mTOR 通路。抗癫痫活性可能是由于作为苯二氮卓 (BZD) 受体配体的额外活性。

高车前素还具有抗骨质疏松、抗动脉粥样硬化、抗痉挛和抗癌功能。它表现出对α-葡萄糖苷酶酶活性的抑制作用。 Hispidulin 抑制血小板聚集，比茶碱更有效。它还充当 γ-氨基丁酸受体 (GABA) 的调节剂，并阻止与皮质神经元相关的谷氨酸突触体的释放。

应用

Hispidulin has been used as a calibration standard:
  • in high-performance liquid chromatography (HPLC) for quantification of Clerodendrum petasites flavonoids
  • in liquid chromatography/electrospray ionization mass spectrometry (LC/ESI-MS) analysis
  • in reverse-phase high-performance liquid chromatography with a diode-array detector (HPLC-DAD) and high-performance thin-layer chromatography (HPTLC)
 

生化/生理作用

Hispidulin is a bioactive flavonoid with a variety of effects including antiproliferative, antifungal, anti-inflammatory, antioxidative and antiepileptic activity. Like EGCG, hispidulin appears to activate AMPK and inhibit the PI3K/Akt/mTOR pathway. The antiepileptic activity may be due to additional activity as a benzodiazepine (BZD) receptor ligand.
Hispidulin also exhibits antiosteoporotic anti-atheromatous, antispasmodic and anticancer functionality. It exhibits inhibition on α-glucosidase enzymatic activity. Hispidulin inhibits platelet aggregation and is more effective than theophylline. It also acts as a modulator of the γ-aminobutyric acid receptor (GABA) and blocks the release of glutamate synaptosomes associated with cortical neurons.
 

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
 
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

储存条件

desiccated

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

储存温度

−20°C

SMILES string

OC1=C(OC)C(O)=C(C(C=C(C2=CC=C(O)C=C2)O3)=O)C3=C1

InChI

1S/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3

InChI key

IHFBPDAQLQOCBX-UHFFFAOYSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 30 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 30
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