苹果酸舒尼替尼，Sunitinib malate；≥98% (HPLC)

图片 苹果酸舒尼替尼，Sunitinib malate；≥98% (HPLC)
别名：舒尼替尼苹果酸盐；SU 11248；N-[2-(二乙氨基)乙基]-5-(5-氟-1,2-二氢-2-氧代-3H-吲哚-3-亚基)甲基]-2,4-二甲基-1H-吡咯-3-甲酰胺盐；N-2-(Diethylamino)ethyl-5-(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioic acid (1:1) salt, SU 011248, SU112248

Empirical Formula (Hill Notation): C22H27FN4O2 · C4H6O5 CAS号: 341031-54-7 分子量: 532.56 MDL编号: MFCD08282795 PubChem化学物质编号: 329823681 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0012
CAS号: 341031-54-7
MDL号: MFCD08282795
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¥976.00

说明

应用

Sunitinib malate has been used:
  • to study its mechanism in the inhibition of MCF-7 cell migration and angiogenesis[1]
  • as a reference molecule to compare its docking energies with other ligands/vascular endothelial growth factor receptor (VEGF) receptor blocker[2]
  • used in proliferation assay[3]

生化/生理作用

Sunitinib has greater bioavailability and potency compared to other inhibitors. It prevents angiogenesis.[4]
Sunitinib malate is a receptor tyrosine kinase inhibitor, which targets VEGF-R1, VEGF-R2, VEGF-R3, PDGF-Rα, PDGF-Rβ, KIT, FLT3, CSF-1R, and RET. Sunitinib malate is an anticancer drug.
 

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
 

其他说明

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

manufacturer/tradename

Pfizer®

溶解性

DMSO: >10 mg/mL

创始人

Pfizer

储存温度

room temp

SMILES string

O[C@@H](CC(O)=O)C(O)=O.CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C

InChI

1S/C22H27FN4O2.C4H6O5/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28;5-2(4(8)9)1-3(6)7/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28);2,5H,1H2,(H,6,7)(H,8,9)/b17-12-;/t;2-/m.0/s1

InChI key

LBWFXVZLPYTWQI-IPOVEDGCSA-N

Gene Information

human ... CSF1R(1436) , FLT1(2321) , FLT3(2322) , FLT4(2324) , KDR(3791) , KIT(3815) , PDGFRA(5156) , PDGFRB(5159) , RET(5979)

 

安全信息

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H360 - H372

危险分类

Repr. 1B - STOT RE 1 Oral

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2 

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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