苯丁酸氮芥 [氯氨布西]，Chlorambucil；97.5-102.5%

图片 苯丁酸氮芥 [氯氨布西]，Chlorambucil；97.5-102.5%
别名：4- [双(2-氯乙基)氨基]苯丁酸, 4-(4-[2-(2-氯乙基)氨基]苯基)丁酸；4-(4-[Bis(2-chloroethyl)amino]phenyl)butyric acid, 4-[Bis(2-chloroethyl)amino]benzenebutyric acid

Empirical Formula (Hill Notation): C14H19Cl2NO2 CAS号: 305-03-3 分子量: 304.21 Beilstein: 999011 EC 号: 206-162-0 MDL编号: MFCD00021783 PubChem化学物质编号: 24278287 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: C0253
CAS号: 305-03-3
MDL号: MFCD00021783
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说明

应用

Chlorambucil has been used:
  • as an alkylating/chemotherapeutic agent to study its anti-inflammatory effects on amyloidogenesis in mice[1]
  • as a positive control to determine the cytotoxicity in murine leukemic monocyte macrophages[2]
  • as an adenine-specific DNA-alkylating reagent in the construction of multifunctional conjugate (8950A-Chb(Cl/OH) for mutation-specific DNA alkylation in HeLa S3 cells[3]

生化/生理作用

苯丁酸氮芥是一种抗癌药物，可使DNA发生烷基化并诱导细胞凋亡。慢性淋巴细胞白血病细胞的死亡可通过p53依赖性机制而发生。
Chlorambucil is a nitrogen mustard alkylating agent[4] that acts as an anti-cancer drug.[5] Chlorambucil binds to membranes, RNA, DNA, and proteins. It exhibits anti-inflammatory[1] and anti-tumor activity by DNA cross-linking.[4] Chlorambucil shows therapeutic effects against chronic lymphocytic leukemia (CLL) via a p53-dependent mechanism.[4]
 
 

属性

形式

powder

质量水平

200

储存温度

2-8°C

SMILES string

OC(=O)CCCc1ccc(cc1)N(CCCl)CCCl

InChI

1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)

InChI key

JCKYGMPEJWAADB-UHFFFAOYSA-N

Gene Information

human ... CYP2D6(1565)

 

安全信息

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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