穿心莲内酯，Andrographolide；Calbiochem®, ≥95% (TLC)

别名：穿心莲乙素；雄茸内酯；二萜内酯类天然抗生素；(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone, ent-(3β,12E,14R)-3,14,19-Trihydroxy-8(17),12-labdadien-16,15-olide, Andrographis

Empirical Formula (Hill Notation): C20H30O5 CAS号: 5508-58-7 分子量: 350.45 MDL编号: MFCD07778082

制造商品牌: 默克 Merck , 西格玛 Sigma-Aldrich

货号（SKU）: 172060

CAS号: 5508-58-7

MDL号: MFCD07778082

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目录价.SKU-Variant

50mg
1g [+¥2,713.87]

¥1,046.35

数量:

说明

一种具有抗病毒，抗炎，抗凋亡和抗血糖特性的双环二萜类似内酯。充当NF-κB和AP-1（IC50≤15µM）激活的不可逆拮抗剂，并防止体外和体内T细胞激活。对IκBα降解，p50和p65核转运没有影响。抑制iNOS和MAC-1表达和ROS产生，并防止小鼠模型中的内毒素休克。此外，据报道激活PI 3K/AKT途径。
NF-κB和AP-1（IC50≤15µM）激活的不可逆转阻滞剂，可显示抗病毒，抗炎，抗凋亡和抗血糖特性。对核转运p50和p65的IκBα降解没有影响。抑制iNOS和MAC-1表达和ROS产生，并防止小鼠模型中的内毒素冲击。据报道，通过激活PI 3-K/AKT途径来抑制细胞色素C的释放和凋亡。

一种具有抗病毒，抗炎，抗凋亡和抗血糖特性的双环二萜类似内酯。A bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties.

一般描述

A bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Acts as an irreversible antagonist of NF-κB and AP-1 (IC₅₀ ≤ 15 µM) activation, and prevents in vitro and in vivo T cell activation. Exerts no effect on IκBα degradation, p50 and p65 nuclear translocation. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in mouse model. Further, reported to activate PI 3K/Akt pathway.

An irreversible blocker of NF-κB and AP-1 (IC₅₀ ≤ 15 µM) activation that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Exerts no effect on IκBα degradation of nuclear translocation p50 and p65. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in a mouse model. Reported to supress Cytochrome C release and apoptosis by activating the PI 3-K/Akt pathway.

生化/生理作用

Cell permeable: no

Primary Target
NF-κB and AP-1 activation

Product does not compete with ATP.

Reversible: no

Target IC₅₀: ≤ 15 µM against NF-κB and AP-1 activation

警告

Toxicity: Carcinogenic / Teratogenic (D)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Xia, Y.F., et al. 2004. J. Immunol.173, 4207.
Chen, J.H., et al. 2004. Biochem. Pharmacol.67, 1337.
Yu, B.C., et al. 2003. Planta Med.69, 1075.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

属性

质量水平

100

测定

≥95% (TLC)

形式

solid

manufacturer/tradename

Calbiochem^®

储存条件

OK to freeze
protect from light

颜色

off-white

溶解性

chloroform: methanol (1:1): 10 mg/mL
DMSO: 15 mg/mL (Use only fresh DMSO.)

运输

ambient

储存温度

2-8°C

InChI

1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15?,16?,17?,19+,20?/m1/s1

InChI key

BOJKULTULYSRAS-ZJFCSBQFSA-N

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格

属性名称	属性值
储存温度 Storage temp.	常温阴凉避光
全球实时库存 Availability √	美国St. Louis ≥ 50 \| 欧洲Eur. ≥ 12 \| 東京Tokyo ≥ 20 \| 香港与北京 ≥ 50

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