硫酸博来霉素 [硫酸博莱霉素]，Bleomycin sulfate from Streptomyces verticillus [BLM]；1.5-2.0 units/mg solid, BioReagent, suitable for cell culture

图片 硫酸博来霉素 [硫酸博莱霉素]，Bleomycin sulfate from Streptomyces verticillus [BLM]；1.5-2.0 units/mg solid, BioReagent, suitable for cell culture
别名："博莱霉素"同"博来霉素"；博来霉素硫酸盐；博莱霉素硫酸盐；Blenoxane；Bleo；Blexane

CAS号: 9041-93-4 EC 号: 232-925-2 MDL编号: MFCD00070310 PubChem化学物质编号: 24891950 NACRES: NA.76
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: B8416
CAS号: 9041-93-4
MDL号: MFCD00070310
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

说明

硫酸博莱霉素是一种从垂直链霉菌中分离的抗肿瘤抗生素。建议用作10-100μg/mL的细胞培养剂。
化学结构：糖肽
博莱霉素与依托泊苷和顺铂联合用于治疗睾丸癌、卵巢癌和宫颈癌。这种组合作为BEP化疗很受欢迎，也被证明是生殖细胞肿瘤中最有效和最成功的化疗方案。由于博来霉素是一种细胞毒性药物，已知它会导致肺血管内皮损伤，称为博来霉素性肺损伤或博来霉质性肺炎（BIP）。研究人员利用博来霉素的这种特性在小鼠和大鼠模型中诱导肺纤维化。
硫酸博莱霉素与DNA结合，导致特定碱基序列的ssDNA断裂，并抑制DNA合成。这种抑制作用需要博来霉素结合氧和金属离子。它还可以在较小程度上但更选择性地切割RNA。它作为细胞凋亡的诱导剂和调节剂，并抑制肿瘤血管生成。

一般描述

Bleomycin Sulfate is an antineoplastic antibiotic isolated from Streptomyces verticillus. It is recommended for use as a cell culture agent at 10-100 μg/mL.
Chemical structure: glycopeptide
 

应用

Bleomycin is used in combination with Etoposide and Cisplatin to treat testicular, ovarian and cervical cancer. This combination is popular as BEP chemotherapy and has also been demonstrated as effective and most successful chemotherapy regimen in germ-cell tumors. Since it is a cytotoxic agent, bleomycin is known to induce endothelial damage the lung vasculature referred to as bleomycin-induced lung-injury or bleomycin-induced pneumonitis (BIP). Researchers have used this property of bleomycin to induce lung fibrosis in mouse and rat models.
 

生化/生理作用

Bleomycin sulfate binds to DNA, causes ssDNA scission at specific base sequences and inhibits DNA synthesis. This inhibitory action requires bleomycin to bind oxygen and a metal ion. It can also cleave RNA, to a lesser degree but more selectively. It acts as an inducer and regulator of apoptosis and inhibits tumor angiogenesis.
 

组分

This product is a mixture of glycopeptides antibiotics containing Bleomycin A2 (70%) and B2(30%). Bleomycins differ from each other in the terminal amine and show varying biological activity.
 

注意

This product should be stored at 2-8°C.
 

制备说明

The product is soluble in water in water at 20 mg/mL and is active for several days. A solution of 2 units/mL in 0.1 M neutral potassium phosphate should be used within 14 days. A solution is active for three months at 3 units/mL in normal saline.
 

其他说明

Keep container tightly closed in a dry and well-ventilated place, strongly hygroscopic
 
 

属性

产品线

BioReagent

质量水平

200

形式

crystalline

specific activity

1.5-2.0 units/mg solid

technique(s)

cell culture | mammalian: suitable

颜色

white

溶解性

H2O: 20 mg/mL, clear, colorless

痕量阳离子

Cu: ≤0.10%

抗生素抗菌谱

fungi

作用机制

DNA synthesis | interferes

储存温度

2-8°C

SMILES string

[O-]S([O-])(=O)=O.C[C@@H](O)[C@@H](NC(=O)[C@@H](C)[C@H](O)[C@@H](C)NC(=O)[C@H](NC(=O)c1nc(nc(N)c1C)[C@H](CC(N)=O)NC[C@H](N)C(N)=O)[C@@H](O[C@@H]2O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]2O[C@@H]3O[C@H](CO)[C@@H](O)[C@@H](OC(N)=O)[C@@H]3O)c4c[nH]cn4)C(=O)NCCc5nc(cs5)-c6ncc(s6)C(=O)NCCC[S+](C)C.C[C@@H](O)[C@@H](NC(=O)[C@@H](C)[C@H](O)[C@@H](C)NC(=O)[C@H](NC(=O)c7nc(nc(N)c7C)[C@H](CC(N)=O)NC[C@H](N)C(N)=O)[C@@H](O[C@@H]8O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]8O[C@@H]9O[C@H](CO)[C@@H](O)[C@@H](OC(N)=O)[C@@H]9O)c%10c[nH]cn%10)C(=O)NCCc%11nc(cs%11)-c%12ncc(s%12)C(=O)NCCC[S+](C)C

InChI

1S/2C55H83N17O21S3.H2O4S/c2*1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-66-26)91-54-43(39(80)37(78)28(16-73)90-54)92-53-40(81)42(93-55(60)88)38(79)29(17-74)89-53)51(87)67-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-68-27(18-94-32)52-65-15-30(95-52)48(84)62-9-7-11-96(5)6;1-5(2,3)4/h2*14-15,18-19,21-25,28-29,34-43,53-54,64,73-75,77-81H,7-13,16-17,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,66,67,69,70,71,72,76,82,83,84,85,86,87,88);(H2,1,2,3,4)/t2*21-,22+,23+,24-,25-,28-,29+,34+,35+,36-,37+,38+,39-,40-,41-,42+,43-,53-,54-;/m00./s1

InChI key

OOXTWFJZZAJGKA-CNLAFNBISA-N

 

安全信息

象形图

Health hazard
GHS08

警示用语：

Danger

危险分类

Carc. 2 - Muta. 1B - Repr. 2

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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