盐酸西替利嗪，Cetirizin dihydrochloride [CTZ]；≥98% (HPLC)

图片 盐酸西替利嗪，Cetirizin dihydrochloride [CTZ]；≥98% (HPLC)
别名：西替利嗪二盐酸盐；[2- [4-[（4-氯苯基）苯基甲基] -1-哌嗪基]乙氧基]乙酸二盐酸盐；[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride

Empirical Formula (Hill Notation): C21H25ClN2O3 · 2HCl CAS号: 83881-52-1 分子量: 461.81 MDL编号: MFCD00941428 PubChem化学物质编号: 329775040
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: C3618
CAS号: 83881-52-1
MDL号: MFCD00941428
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说明

应用

Cetirizine dihydrochloride has been used as an antagonist for histamine receptors H1 in HSDSEAP (poly) clonal cells derived from human embryonic kidney HEK-293 cells.[1] It has also been used as a ligand in the crystallization of equine serum albumin cetirizine complex.[2]
 

生化/生理作用

Cetirizine hydrochloride is an orally active and selective H1-receptor antagonist. Antihistaminic; Piperazines. Non-sedating type histamine H1-receptor antagonist; major metabolite of hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer.
Cetirizine is a racemic mixture of (R)-levocetirizine and (S)-dextrocetirizine.[3] It exists as a zwitterion at acidic pH and gets absorbed by passive diffusion. Cetirizine is a prescribed drug for allergic rhinitis and chronic idiopathic urticaria.[4]
 

特点和优势

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

H2O: 5 mg/mL, clear

创始人

Pfizer

相关疾病

allergies

SMILES string

OC(COCCN1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1)=O.[H]Cl.[H]Cl

InChI

1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H

InChI key

PGLIUCLTXOYQMV-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

 

安全信息

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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