盐酸强力霉素 [盐酸多西环素]，Doxycycline hyclate；Pharmaceutical Secondary Standard; Certified Reference Material

图片 盐酸强力霉素 [盐酸多西环素]，Doxycycline hyclate；Pharmaceutical Secondary Standard; Certified Reference Material
别名：盐酸强力霉素标准品；盐酸多西环素标准品；强力霉素盐酸盐；多西环素盐酸盐；多西环素单盐酸半乙醇半水合物；Doxycycline hydrochloride hemiethanolate hemihydrate；脱氧土霉素盐酸盐；6-甲基-4-(二甲氨基)-3,5,10,12,12a-五羟基-1,11-二氧代-1,4,4a,5,5a,6,11,12a-八氢-2-并四苯甲酰胺盐酸盐

Empirical Formula (Hill Notation): C22H24N2O8 · HCl · 0.5H2O · 0.5C2H6O CAS号: 24390-14-5 分子量: 512.94 Beilstein: 5702728 MDL编号: MFCD07357237 PubChem化学物质编号: 329823165
制造商品牌: 西格玛 Sigma-Aldrich , 色谱科 Supelco
货号（SKU）: PHR1145
CAS号: 24390-14-5
MDL号: MFCD07357237
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

说明

四环素的半合成类似物多西环素是一种用于医学和兽医应用的广谱抗生素，以其对大量革兰氏阳性和革兰氏阴性细菌的作用而闻名。它是针对立克次体、支原体和衣原体传播的感染开出的处方。
盐酸多西环素可用作通过各种色谱和分光光度法测定药物制剂和生物样品中分析物的药物参考标准。

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Doxycycline, the semi-synthetic analog of tetracycline, is a broad-spectrum antibiotic employed in medicine and veterinary applications, is known for its action against a huge range of gram positive and gram negative bacteria. It is prescribed against infections spread by rickettsiae, mycoplasmas and chlamydiae.
 

应用

Doxycycline hyclate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and biological samples by various chromatography and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
 

生化/生理作用

盐酸强力霉素可抑制莱姆病伯氏螺旋体引起的炎症反应。 它在体内是一种广谱的基质金属蛋白酶抑制剂。
 

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
 

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Values of analytes vary lot to lot.
 

附注

To see an example of a Certificate of Analysis for this material enter LRAC0269 in the slot below. This is an example certificate only and may not be the lot that you receive.
 
 

属性

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 780
traceable to Ph. Eur. D3000000
traceable to USP 1226003

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

-10 to -25°C

SMILES string

Cl[H].Cl[H].[H]O[H].CCO.C[C@@H]1C2[C@H](O)C3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14.C[C@@H]5C6[C@H](O)C7[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]7(O)C(O)=C6C(=O)c8c(O)cccc58

InChI

1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h2*4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);3H,2H2,1H3;2*1H;1H2/t2*7-,10?,14?,15-,17-,22-;;;;/m00..../s1

InChI key

HALQELOKLVRWRI-ZVACAFRPSA-N

 

安全信息

警示用语：

Warning

危险分类

Aquatic Acute 1 - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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