盐酸吡咯列酮；Pioglitazone hydrochloride；≥98% (HPLC)

图片 盐酸吡咯列酮；Pioglitazone hydrochloride；≥98% (HPLC)
别名：盐酸匹格列酮；一种PPARγ刺激剂；吡格列酮盐酸盐；匹格列酮盐酸盐；5- [4- [2-（5-乙基-2-吡啶基）乙氧基]苄基]噻唑烷-2,4-二酮盐酸盐；5-[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]benzyl]thiazolidine-2,4-dione hydrochloride；Pioglitazone hydrochloride；Pioglitazone HCl

Empirical Formula (Hill Notation): C19H20N2O3S · HCl CAS号: 112529-15-4 分子量: 392.90 MDL编号: MFCD04975446 PubChem化学物质编号: 329799001 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: E6910
CAS号: 112529-15-4
MDL号: MFCD04975446
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说明

盐酸吡格列酮由I型和II型多晶型组成。它是一种口服抗糖尿病药物，属于噻唑烷二酮类。
 
已使用盐酸吡格列酮：
向小鼠模型施用并处理肝癌细胞系，以研究其对饮食诱导肥胖（DIO）C57BL/6小鼠中胰岛素降解酶（IDE）的调节作用
分析其对Goto Kakizaki（GK）2型糖尿病大鼠心室肌细胞缩短和钙转运的影响
用过氧化物酶体增殖物激活受体γ（PPARγ）激动剂治疗HepG2细胞，以检测其对TOMM40-、APOE-和APOC1 mRNA水平的影响

一般描述

Pioglitazone hydrochloride consists of poly-morphs, form I and form II. It is an oral antidiabetic agent, that is a member of the thiazolidinedione group.
 

应用

Pioglitazone hydrochloride has been used:
  • to administer to mice model and treated the hepatoma cell line to study its effect on regulating insulin-degrading enzyme (IDE) in diet-induced obese (DIO) C57BL/6 mice
  • in drug preparation to analyze its effects on shortening and calcium transport in ventricular myocytes from the Goto-Kakizaki (GK) type 2 diabetic rat
  • to treat HepG2 cells with peroxisome proliferator-activated receptor γ (PPARγ) agonists to examine its effect on TOMM40-, APOE- and APOC1-mRNA levels

生化/生理作用

盐酸吡格列酮是一种PPARγ激动剂和噻唑烷二酮（TZD）抗糖尿病药物。吡格列酮是一种核受体过氧化物酶体增殖物激活受体γ（PPAR-γ）的选择性激动剂，并在较小程度上是PPAR-α。
Pioglitazone hydrochloride is usually used to treat type-II diabetes. It has the ability to block hepatic gluconeogenesis.
 

特点和优势

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the AMPKs and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Takeda. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

颜色

white to off-white

溶解性

DMSO: ≥10 mg/mL

创始人

Takeda

储存温度

room temp

SMILES string

Cl.CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1

InChI

1S/C19H20N2O3S.ClH/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17;/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23);1H

InChI key

GHUUBYQTCDQWRA-UHFFFAOYSA-N

Gene Information

human ... PPARG(5468)

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

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