甘氨酸钠盐水合物，Glycine sodium salt hydrate；≥99% (HPLC)

图片 甘氨酸钠盐水合物，Glycine sodium salt hydrate；≥99% (HPLC)
线性分子式: H2NCH2CO2Na · xH2O CAS号: 207300-76-3 分子量: 97.05 (anhydrous basis) MDL编号: MFCD00150683 eCl@ss: 32160406 PubChem化学物质编号: 24895270
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: G6761
CAS号: 207300-76-3
MDL号: MFCD00150683
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说明

甘氨酸是由胆碱、苏氨酸和丝氨酸合成的。它是卟啉、嘌呤、谷胱甘肽和肌酸的前体。
甘氨酸钠盐水合物被用作蛋白质提取和电泳缓冲液中整个肌肉匀浆的缓冲液成分。它也被用作斑马鱼脊髓切片免疫组织化学染色的神经递质。
甘氨酸钠盐水合物已用于肌肉组织的均质化，并作为电泳缓冲液的组成部分，用于分析从五种干旱鲶鱼物种（Ariopsis felis、Bagre marinus、Cathodorops aguadulosis、Cathodrops fuerthii和Ariopsi guatemalensis）获得的全肌蛋白。
甘氨酸对调节免疫功能、新陈代谢、生长发育至关重要。它调节细胞内Ca2+水平和细胞因子的产生。肥胖、2型糖尿病（T2DM）和非酒精性脂肪肝（NAFLD）患者的甘氨酸水平降低。细胞质中的甘氨酸-丝氨酸羟甲基转移酶1将甘氨酸降解为丝氨酸。

一般描述

Glycine is synthesized from choline, threonine and serine. It serves as a precursor for porphyrins, purines, glutathione and creatine.

应用

Glycine sodium salt hydrate has been used as a component of buffer for homogenization of whole muscle for protein extraction and in electrophoresis buffer. It has also been used as a neurotransmitter in immunohistochemical staining of Zebrafish spinal cord sections.
Glycine sodium salt hydrate has been used for homogenization of muscle tissue and as a component of buffer for electrophoresis, for analysis of whole muscle proteins obtained from five ariid catfish species: Ariopsis felis, Bagre marinus, Cathorops aguadulce, Cathorops fuerthii and Ariopsis guatemalensis.
 

生化/生理作用

Glycine is essential for the regulation immune function, metabolism, growth and development. It modulates intracellular Ca2+ levels and cytokines production. A reduction in glycine levels is observed in obesity, type 2 diabetes (T2DM), and non-alcoholic fatty liver disease (NAFLDs). Glycine is degraded to serine by glycine serine hydroxymethyltransferase 1 in cytoplasm.
 
 

属性

质量水平

300

测定

≥99% (HPLC)

mp

197-201 °C (lit.)

SMILES string

[Na+].[H]O[H].NCC([O-])=O

InChI

1S/C2H5NO2.Na.H2O/c3-1-2(4)5;;/h1,3H2,(H,4,5);;1H2/q;+1;/p-1

InChI key

CIJQGPVMMRXSQW-UHFFFAOYSA-M

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

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