环噻嗪，Cyclothiazide；≥98%

图片 环噻嗪，Cyclothiazide；≥98%
别名：莰烯氯噻嗪；6-Chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2-4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Empirical Formula (Hill Notation): C14H16ClN3O4S2 CAS号: 2259-96-3 分子量: 389.88 EC 号: 218-859-7 MDL编号: MFCD00210192 PubChem化学物质编号: 24278350 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: C9847
CAS号: 2259-96-3
MDL号: MFCD00210192
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¥1,398.94

说明

Cyclothiazide 是一种苯并噻二嗪，其结构与二氮嗪相似。

Cyclothiazizide 已被用作 α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体 (AMPAR) 脱敏阻滞剂，以研究 γ2 对受体脱敏的影响。

阻断 AMPA 谷氨酸受体的快速脱敏，并显着延长诱发的兴奋性突触后电流的衰减时间。

一般描述

Cyclothiazide is a benzothiadiazine, which has a similar structure to diazoxide.
 

应用

Cyclothiazide has been used as a α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) desensitization blocker to study the effects of γ2 on receptor desensitization.
 

生化/生理作用

Blocks the rapid desensitization of the AMPA glutamate receptors and markedly prolongs the decay time of the evoked excitatory post-synaptic current.
 

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 
 

属性

形式

powder

质量水平

200

创始人

Eli Lilly

储存温度

2-8°C

SMILES string

[H][C@@]12CC(C3Nc4cc(Cl)c(cc4S(=O)(=O)N3)S(N)(=O)=O)[C@@]([H])(C1)C=C2

InChI

1S/C14H16ClN3O4S2/c15-10-5-11-13(6-12(10)23(16,19)20)24(21,22)18-14(17-11)9-4-7-1-2-8(9)3-7/h1-2,5-9,14,17-18H,3-4H2,(H2,16,19,20)/t7-,8+,9?,14?/m0/s1

InChI key

BOCUKUHCLICSIY-QJWLJZLASA-N

Gene Information

human ... CA1(759) , CA4(762) , GRIA1(2890) , GRIA2(2891) , GRIA3(2892) , GRIA4(2893)
rat ... Gria1(50592)

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 2

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 30 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 30
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