氯霉素，Chloramphenicol；BioReagent, suitable for plant cell culture, ≥98.0%

图片 氯霉素，Chloramphenicol；BioReagent, suitable for plant cell culture, ≥98.0%
别名：D-苏式-(-)-N-[α-(羟基甲基)-β-羟基-对硝基苯乙基]-2,2-二氯乙酰胺；(1R,2R)-N-[α-(羟基甲基)-β-羟基-对硝基苯乙基]-2,2-二氯乙酰胺；D-(-)-苏-1-对硝基苯基-2-二氯乙酰胺基-1,3-丙二醇；左旋霉素；左旋-苏-1-(对硝基苯基)-2-二氯乙酰氨基-1,3-丙二醇；D(−)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide, D-(−)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol, D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide, Chloromycetin

线性分子式: Cl2CHCONHCH(CH2OH)CH(OH)C6H4NO2 CAS号: 56-75-7 分子量: 323.13 Beilstein: 2225532 EC 号: 200-287-4 MDL编号: MFCD00078159 PubChem化学物质编号: 24892448 NACRES: NA.76
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: C1919
CAS号: 56-75-7
MDL号: MFCD00078159
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说明

一般描述

Chemical structure: phenicole
 

应用

Chloramphenicol is a synthetic antibiotic, isolated from strains of Streptomyces venezuelae. It is often used for bacterial selection in molecular biology applications at 10-20 μg/mL and as a selection agent for transformed cells containing chloramphenicol reistance genes.
 

生化/生理作用

作用机制：氯霉素通过与50S核糖体亚基结合并阻止氨酰基tRNA附着于核糖体来阻断肽基转移酶步骤，从而抑制细菌蛋白质的合成。 它还抑制线粒体和叶绿体蛋白的合成以及（p）ppGpp的核糖体形成，从而抑制rRNA的转录。

耐药性机制：使用氯霉素乙酰转移酶会使产物乙酰化并使其失活。
抗菌谱：这是一种针对革兰氏阳性和革兰氏阴性细菌的广谱抗生素，主要用于眼科和兽医目的。
 

注意

Stock solutions should be stored at 2-8°C and are stable at 37°C for 5 days. Aqueous solutions are neutral and stable over a wide pH range, with 50% hydrolysis occurring after 290 days. Use of a borax buffered solution reduces this number to 14%. Solutions should be protected from light as photochemical decomposition results in a yellowing of the solution. Heating aqueous solutions at 115°C for 30 minutes results in a 10% loss of chloramphenicol.
 

制备说明

Stock solutions can be prepared directly in the vial at any recommended concentration. A solution at 50 mg/mL in ethanol yields a clear, very faint, yellow solution. Degradation of chloramphenicol in aqueous solution is catalyzed by general acids and bases. This rate of degradation is independent of the ionic strength and pH.
 

其他说明

Keep container tightly closed in a dry and well-ventilated place, Light sensitive. Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
 
 

属性

产品线

BioReagent

质量水平

200

形式

powder

technique(s)

cell culture | plant: suitable

杂质

Endotoxin, tested

mp

148-150 °C (lit.)

溶解性

ethanol: 50 mg/mL

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mycoplasma

application(s)

agriculture

作用机制

protein synthesis | interferes

SMILES string

OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O

InChI

1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1

InChI key

WIIZWVCIJKGZOK-RKDXNWHRSA-N

Gene Information

human ... CYP1A2(1544)

 

安全信息

象形图

CorrosionHealth hazard
GHS05,GHS08

警示用语：

Danger

危险分类

Carc. 2 - Eye Dam. 1 - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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