氯唑西林钠盐一水合物，Cloxacillin sodium salt monohydrate；β-lactamase-resistant antibiotic

图片 氯唑西林钠盐一水合物，Cloxacillin sodium salt monohydrate；β-lactamase-resistant antibiotic
别名：一种耐β-内酰胺酶的抗生素；一水氯唑西林钠；邻氯西林钠一水合物；氯唑西林钠水合物；邻氯青霉素钠；4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid；6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, sodium salt, (2S,5R,6R)- (1:1); Sodium (2S,5R,6R)-6-({[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; [(5R,6R)-6-({[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylato-kappaO]sodium hydrate (1:1)

线性分子式: C19H17ClN3O5SNa · H2O CAS号: 7081-44-9 分子量: 475.88 EC 号: 211-390-9 MDL编号: MFCD00150735 PubChem化学物质编号: 24893156 NACRES: NA.85
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: C9393
CAS号: 7081-44-9
MDL号: MFCD00150735
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说明

化学结构：ß-内酰胺
氯唑西林对青霉素G耐药葡萄球菌引起的感染有效。它被用于研究烧伤和挤压伤口的局部抗菌剂。
氯唑西林是一种半合成抗生素，也是苯唑西林的氯化衍生物。它通过结合青霉素结合蛋白（PBPs）抑制细菌细胞壁合成的最后阶段，从而导致细胞裂解。细胞裂解由细菌细胞壁自溶酶介导。Cloxacillin常与β-内酰胺类抗生素一起用作AmpCβ内酰胺酶抑制剂。

一般描述

Chemical structure: ß-lactam
 

应用

Cloxacillin is effective against infections caused by penicillin G-resistant staphylococci. It was used in studies of topical antibacterial agents for burn and crush wounds.
 

生化/生理作用

Cloxacillin is a semi-synthetic antibiotic and a chlorinated derivative of oxacillin. It inhibits the last stage of bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. Cloxacillin is often used as AmpC β-lactamase inhibitor in combination with β-lactam antibiotics.
 

其他说明

Keep container tightly closed in a dry and well-ventilated place.
 
 

属性

质量水平

200

形式

powder or crystals

抗生素抗菌谱

Gram-positive bacteria

作用机制

cell wall synthesis | interferes

储存温度

2-8°C

SMILES string

O.[Na+].Cc1onc(-c2ccccc2Cl)c1C(=O)N[C@H]3[C@H]4SC(C)(C)[C@@H](N4C3=O)C([O-])=O

InChI

1S/C19H18ClN3O5S.Na.H2O/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23;;/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1../s1

InChI key

KCUWTKOTPIUBRI-VICXVTCVSA-M

 

安全信息

象形图

Exclamation markHealth hazard
GHS07,GHS08

警示用语：

Danger

危险分类

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 2

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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